Low ratio of n3:n6 fatty acids correlates with CAD progression

January 23, 2013
Low ratio of n3:n6 fatty acids correlates with CAD progression
For statin-treated patients with coronary artery disease, decreases in the ratio of serum n-3 to n-6 polyunsaturated fatty acids correlate with atherosclerosis progression, according to research published in the Jan. 1 issue of The American Journal of Cardiology.

(HealthDay)—For statin-treated patients with coronary artery disease, decreases in the ratio of serum n-3 to n-6 polyunsaturated fatty acids (PUFAs) correlate with atherosclerosis progression, according to research published in the Jan. 1 issue of The American Journal of Cardiology.

Tsuyoshi Nozue, M.D., of the Yokohama Sakae Kyosai Hospital in Japan, and colleagues evaluated the effects of serum n-3 to n-6 PUFA ratios on in 101 statin-treated patients with coronary artery disease who were evaluated using virtual histology ultrasound. The patients were assessed at the time of percutaneous coronary intervention and after eight months of statin therapy.

At follow-up, the researchers found that 46 percent of patients showed atheroma progression and 54 percent exhibited atheroma regression. There were significant negative correlations seen for the change in plaque volume and in the change in fibrous component volume with the changes in the ratios of eicosapentaenoic acid (EPA)/arachidonic acid (AA), docosahexaenoic acid (DHA)/AA, and EPA+DHA/AA. The change in EPA+DPA/AA ratio was a significant predictor of the percentage change in both plaque volume and fibrous component volume in multivariate analysis.

"In conclusion, decreases in serum n-3 to n-6 polyunsaturated fatty acid ratios are associated with progression in coronary atherosclerosis evaluated using virtual histology intravascular ultrasound in statin-treated patients with ," the authors write.

Explore further: Coronary artery spasms rare during dobutamine stress echo

More information: Abstract
Full Text

Related Stories

Coronary artery spasms rare during dobutamine stress echo

March 9, 2012

(HealthDay) -- The occurrence of coronary artery spasm (CAS) during dobutamine stress echocardiography (DSE) is rare, with a prevalence of 0.4 percent, according to a study published in the March 15 issue of The American ...

Recommended for you

Smoking leaves lasting marks on DNA, study finds

September 20, 2016

(HealthDay)—Smoking cigarettes can leave a lasting imprint on human DNA, altering more than 7,000 genes in ways that may contribute to the development of smoking-related diseases, a new study says.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.