Statin use linked to reduced risk of hepatocellular cancer
Statin use is associated with a reduced risk of hepatocellular carcinoma, most strongly in Asian populations, according to a meta-analysis published in the February issue of Gastroenterology.
(HealthDay)—Statin use is associated with a reduced risk of hepatocellular carcinoma (HCC), most strongly in Asian populations, according to a meta-analysis published in the February issue of Gastroenterology.
Siddharth Singh, M.B.B.S., from the Mayo Clinic in Rochester, Minn., and colleagues conducted a systematic literature review and meta-analysis of studies that evaluated the effects of statins on the risk of HCC. The analysis included 10 studies reporting 4,298 cases of HCC in 1,459,417 patients.
The researchers found that, compared with statin nonusers, statin users were significantly less likely to develop HCC (adjusted odds ratio [aOR], 0.63), although there was considerable heterogeneity in the results (P = 0.01; I² = 59 percent). Suggested sources of this heterogeneity included study location (Asian population [four studies]: aOR, 0.52; Western population [six studies]: aOR, 0.67) and study design (observational studies [seven studies]: aOR, 0.60; clinical trials [three studies]: aOR, 0.95; 95 percent confidence interval, 0.62 to 1.45).
"In summary, our meta-analysis suggests that use of statins is associated with a reduced risk of HCC," the authors write. "However, these results should be interpreted with caution given the possibility of residual confounding. Future randomized clinical trials or prospective cohort studies in populations at high risk for HCC (especially in the Asian hepatitis B virus-infected population) are warranted."
Journal reference: Gastroenterology
- Risks of esophagus cancer studied: Statins may protect against esophageal cancer Oct 22, 2012 | not rated yet | 0
- Hepatitis B virus mutations may predict risk of liver cancer Jul 02, 2009 | not rated yet | 0
- Study indicates cancer preventive effect for statins May 05, 2009 | not rated yet | 0
- Incidence of recurrent anal sphincter rupture is 7.1 percent Oct 26, 2012 | not rated yet | 0
- Family history of liver cancer increases risk of developing the disease Apr 24, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
In recent years, microRNAs (miRNAs) and other non-coding RNAs are small molecules that help control the expression of specific proteins. In recent years they have emerged as disease biomarkers. miRNA profiles have been used ...
Cancer 2 hours ago | not rated yet | 0
Cancer cells spread and grow by avoiding detection and destruction by the immune system. Stimulation of the immune system can help to eliminate cancer cells; however, there are many factors that cause the immune system to ...
Cancer 2 hours ago | not rated yet | 0
Researchers from London's Kingston University have begun a two-year study which could help prolong the lives of people with colorectal tumours.
Cancer 5 hours ago | 5 / 5 (1) | 0
Transformative research from Western University has identified new hormones in the body which may suppress breast cancer and stimulate the regression of breast tumors.
Cancer 6 hours ago | 5 / 5 (1) | 0
(Medical Xpress)—Curtin University researchers have found evidence that targeting specific cells in the body can reverse the effects of cancer on the immune system.
Cancer 6 hours ago | 5 / 5 (3) | 0
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
6 minutes ago | not rated yet | 0 |
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
47 minutes ago | not rated yet | 0
(AP)—Government health officials are investigating several health problems reported with potentially contaminated medications made by a Tennessee specialty pharmacy.
56 seconds ago | not rated yet | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
5 hours ago | 5 / 5 (3) | 0 |
2 hours ago | not rated yet | 0 |
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
3 hours ago | 5 / 5 (2) | 0 |