New study points to the aggressive potential of small kidney tumours, advocates treatment

March 18, 2013

Small kidney tumours have an agressive potential and should be treated, according to a the results of a large multicentre study presented at the 28th Annual EAU Congress in Milan.

"Many clinicians regard small as having a benign biologic behavior and non-operative surveillance protocols are often being used in patients with small renal tumours," write the authors in the findings. "The aim of this large retrospective multi-centre study was to evaluate the prevalence of locally advanced growth and distant metastases in patients with small renal following surgery."

The investigation included 2197 patients with RCC of 4 cm or smaller in maximal tumour diameter and complete patient and tumour specific characteristics from six centers in Germany between 1990 and 2011.

The risk of presenting nodal disease or distant metastasis increased insignificantly with rising tumour diameter. After a mean follow-up of more than 5 years, the tumour-associated were 6.5, 7.6, and 8.4 % in the ≤ 2 cm, 2-3 cm, and 3-4 cm tumour diameter subgroups, respectively. Kaplan-Meier 5-year cancer specific survival (CSS) rates did not differ significantly: 93.3, 92.1, and 92.8 %.

Patients with no lymphatic or distant metastasis at the time of diagnosis or surgery had a 5-year cancer specific death rate of 5.8 %. 5-year cancer related death rate was significantly higher among the 75 patients with nodal or distant involvement at the time of surgery (p<0.001).

In conclusion, the authors stress that lymph node and distant occur even in small RCCs: "These results have significant implications since the rate of patients diagnosed with small renal masses is increasing and non-operative surveillance protocols are currently being used in patients with small renal tumour."

Related Stories

Recommended for you

Study reveals new insight into DNA repair

August 3, 2015

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks ...

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.