Blood pressure changes warn of premature death for African Americans with kidney disease

Large fluctuations in blood pressure from day to day are a warning sign for African Americans with kidney disease, indicating that they may face an increased risk of dying prematurely. That is the conclusion of a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings highlight the importance of routine blood pressure monitoring in patients with kidney disease, and they suggest that treatments that address large fluctuations may improve health.

African Americans are more likely than whites to develop kidney disease. Doctors can find it difficult to predict which of their with kidney disease have the highest risk of dying prematurely; however, they do know that cardiovascular disease is most common cause of death in individuals with kidney disease and that there is a strong correlation between blood pressure and kidney .

To investigate the role of blood pressure in African American kidney disease patients' health, Ciaran McMullan, MD (Brigham and Women's Hospital) and his colleagues studied 908 African American adults who had kidney disease due to . The participants had at least one year of blood pressure measurements available, and they were followed for three to 6.4 years.

The researchers found that patients whose blood pressure changed significantly from day to day were nearly three times as likely to die from any cause during the study (and nearly six times as likely to die from heart-related problems) than patients whose blood pressure changed very little from day to day.

"Larger changes in blood pressure from day to day could identify a high risk group of African Americans with ," said Dr. McMullan. "In addition, it means that scientists should examine why people have large day to day variations in blood pressure, as this may turn out to be a new area of therapy research."

"This could mean that doctors should start paying attention not only to what the blood pressure is on the day you see him or her, but also on whether it is changing a lot each time he or she sees you," said Dr. McMullan.

More information: The article, entitled "Association of Blood Pressure Variability with Mortality Among African Americans with Chronic Kidney Disease," will appear online on March 14, 2013, doi: 10.2215/CJN.10131012

add to favorites email to friend print save as pdf

Related Stories

Metabolic syndrome may cause kidney disease

Aug 19, 2011

Metabolic syndrome comprises a group of medical disorders that increase people's risk of diabetes, heart disease, stroke, and premature death when they occur together. A patient is diagnosed with the syndrome when he or she ...

Gene linked to worsening kidney disease in African-Americans

Nov 21, 2010

In African Americans with kidney disease related to hypertension (high blood pressure), a common gene variant is associated with a sharply increased risk of progressive kidney disease, according to a study presented at the ...

Recommended for you

Kidney-brain connection may help drive chronic kidney disease

2 hours ago

In addition to affecting blood pressure, high-salt intake can promote kidney function decline in patients with chronic kidney disease. A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (J ...

Flu's grip on U.S. starting to weaken: CDC

2 hours ago

(HealthDay)—After a rough start to the flu season, the number of infections seems to have peaked and is even starting to decline in many parts of the nation, federal health officials reported Thursday.

Litchi fruit suspected in mystery illness in India

2 hours ago

A mysterious and sometimes fatal brain disease that has afflicted children in northeastern India for years could be linked to a toxic substance in litchi fruits, US researchers said Thursday.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.