Women smokers may have greater risk for colon cancer than men

Smoking increased the risk for developing colon cancer, and female smokers may have a greater risk than male smokers, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Globally, during the last 50 years, the number of new cases per year has exploded for both men and ," said Inger Torhild Gram, M.D., Ph.D., professor in the Department of Community Medicine at the University of Tromsø in Norway. "Our study is the first that shows women who smoke less than men still get more colon cancer."

Gram and her colleagues examined the association between cigarette and colon cancer, by tumor location, in a large Norwegian cohort of more than 600,000 men and women. The participants from four surveys initiated by the National Health Screening Service of the Norwegian Institute of Public Health had a short health exam and completed questionnaires about smoking habits, physical activity and other lifestyle factors. The participants were followed by linkage to the Cancer Registry of Norway and the Central Population Register. During an average 14 years of follow-up, close to 4,000 new colon cancer cases were diagnosed.

Gram and colleagues found that had a 19 percent increased risk compared with never-smokers, while had an 8 percent increased risk compared with never-.

In addition, women who started smoking when they were 16 or younger and women who had smoked for 40 years or more had a substantially increased risk, by about 50 percent. Also, the dose-response association between the number of cigarettes smoked per day, number of years smoked and number of pack-years smoked and colon cancer risk was stronger for women than it was for men.

"The finding that women who smoke even a moderate number of cigarettes daily have an increased risk for colon cancer will account for a substantial number of new cases because colon cancer is such a common disease," said Gram. "A causal relationship between smoking and colorectal cancer has recently been established by the International Agency for Research on Cancer of the World Health Organization, but unfortunately, this is not yet common knowledge, neither among health personnel nor the public."

add to favorites email to friend print save as pdf

Related Stories

Smokers might benefit from earlier colon cancer screening

Feb 13, 2008

New evidence suggests screening for colorectal cancer, which is now recommended to begin at age 50 for most people, should start five to 10 years earlier for individuals with a significant lifetime exposure to tobacco smoke, ...

Study finds smoking related to subset of colorectal cancers

Apr 14, 2008

Smoking puts older women at significant risk for loss of DNA repair proteins that are critical for defending against development of some colorectal cancers, according to research from a team led by Mayo Clinic scientists.

Recommended for you

Dog's epigenome gives clues to human cancer

1 hour ago

The bond between humans and dogs is strong and ancient. From being the protector of the first herds in a faithful pet, dogs and people share many aspects of life. The relationship between the two species ...

Study pinpoints microRNA tied to colon cancer tumor growth

17 hours ago

Researchers at the University of Minnesota have identified microRNAs that may cause colon polyps from turning cancerous. The finding could help physicians provide more specialized, and earlier, treatment before colon cancer ...

User comments