Strong genetic component of fibromyalgia suggested

Strong genetic component of fibromyalgia suggested
A genome-wide linkage scan has identified the chromosome 17p11.2-q11.2 region as the susceptibility locus for fibromyalgia, according to research published in the April issue of Arthritis & Rheumatism.

(HealthDay)—A genome-wide linkage scan has identified the chromosome 17p11.2-q11.2 region as the susceptibility locus for fibromyalgia, according to research published in the April issue of Arthritis & Rheumatism.

Lesley M. Arnold, M.D., of the University of Cincinnati College of Medicine, and colleagues genotyped members from 116 families from the Fibromyalgia Family Study and performed a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.

According to the researchers, based on a 2 percent population prevalence of fibromyalgia, the sibling recurrence risk ratio for fibromyalgia was estimated to be 13.3. Model-free linkage analysis identified one major locus for fibromyalgia at the D17S2196 and D17S1294 markers on the chromosome 17p11.2-q11.2.

"In conclusion, we detected genome-wide suggestive linkage to the chromosome 17p11.2-q11.2 region in a cohort of multi-case families from the Fibromyalgia Study," the authors write. "Further comprehensive sequencing analyses of the 17p11.2-q11.2 chromosome region in multi-case families are warranted to identify potential causal genetic risk variants for ."

One author disclosed providing expert testimony for administrative law judges of the Office of Disability Adjudication and Review of the Social Security Administration.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

New Canadian guidelines for treating fibromyalgia

May 06, 2013

Physicians from the McGill University Health Centre (MUHC) and the University of Calgary have published a review article in the CMAJ (Canadian Medical Association Journal) to help family doctors diagnose and treat fibromy ...

Recommended for you

Osteoarthritis patients will benefit from jumping exercise

Feb 18, 2015

Progressive high-impact training improved the patellar cartilage quality of the postmenopausal women who may be at risk of osteoporosis (bone loss) as well as at risk of osteoarthritis. This was found out in the study carry ...

Use of nondrug, nonsurgical options low in hip, knee OA

Feb 16, 2015

(HealthDay)—Usage of nondrug, nonoperative interventions in community-dwelling individuals with hip and knee osteoarthritis (OA) is low, according to research published in the February issue of Arthritis Ca ...

Prevalence of fibromyalgia varies with criteria applied

Feb 13, 2015

(HealthDay)—The prevalence of fibromyalgia varies with the different sets of the American College of Rheumatology (ACR) classification criteria, according to a study published in the February issue of Arthritis & ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.