Strong genetic component of fibromyalgia suggested

May 11, 2013
Strong genetic component of fibromyalgia suggested
A genome-wide linkage scan has identified the chromosome 17p11.2-q11.2 region as the susceptibility locus for fibromyalgia, according to research published in the April issue of Arthritis & Rheumatism.

(HealthDay)—A genome-wide linkage scan has identified the chromosome 17p11.2-q11.2 region as the susceptibility locus for fibromyalgia, according to research published in the April issue of Arthritis & Rheumatism.

Lesley M. Arnold, M.D., of the University of Cincinnati College of Medicine, and colleagues genotyped members from 116 families from the Fibromyalgia Family Study and performed a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.

According to the researchers, based on a 2 percent population prevalence of fibromyalgia, the sibling recurrence risk ratio for fibromyalgia was estimated to be 13.3. Model-free linkage analysis identified one major locus for fibromyalgia at the D17S2196 and D17S1294 markers on the chromosome 17p11.2-q11.2.

"In conclusion, we detected genome-wide suggestive linkage to the chromosome 17p11.2-q11.2 region in a cohort of multi-case families from the Fibromyalgia Study," the authors write. "Further comprehensive sequencing analyses of the 17p11.2-q11.2 chromosome region in multi-case families are warranted to identify potential causal genetic risk variants for ."

One author disclosed providing expert testimony for administrative law judges of the Office of Disability Adjudication and Review of the Social Security Administration.

Explore further: New Canadian guidelines for treating fibromyalgia

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

New Canadian guidelines for treating fibromyalgia

May 6, 2013

Physicians from the McGill University Health Centre (MUHC) and the University of Calgary have published a review article in the CMAJ (Canadian Medical Association Journal) to help family doctors diagnose and treat fibromyalgia. ...

Recommended for you

The promise of precision medicine for rheumatoid arthritis

November 21, 2016

In a new study, a Yale-led research team identified the mechanism of a gene that raises the risk of severe rheumatoid arthritis in susceptible individuals. The finding may lead to the development of treatment based on the ...

Back pain link to 24-hour body clock revealed

August 4, 2016

New research by University of Manchester scientists has for the first time shown that our spinal discs have 24-hour body clocks which when they malfunction, can contribute to lower back pain.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.