Men with restless legs syndrome may be at higher risk of early death

Men who experience restless legs syndrome (RLS) may have a higher risk of dying earlier, according to research that appears in the June 12, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology. The disorder is characterized by an irresistible urge to move the legs and often causes leg sensations of burning, creeping, and tugging, which are usually worse at night.

"RLS affects five to 10 percent of adults across the country," said study author Xiang Gao, MD, PhD, with Harvard School of Public Health, Harvard Medical School and the Channing division of network , Brigham & Women's Hospital in Boston. Gao is also a member of the American Academy of Neurology. "Our study highlights the importance of recognizing this common but underdiagnosed disease."

For the study, 18,425 men with an average age of 67 who did not have diabetes, arthritis or kidney failure were evaluated for RLS. A total of 690 of the men, or 3.7 percent, met the criteria for at the beginning of the study. Information about major chronic diseases was collected every two years. During the eight years of study follow-up, 2,765 of the participants died. Of the people with RLS, 171, or 25 percent, died during the study, compared to 2,594, or 15 percent, of those who did not have RLS.

The study found that men with RLS had a nearly 40 percent increased risk of death compared to without RLS. The association dropped only slightly after adjusting for factors such as body mass index, lifestyle, chronic conditions, lack of sleep and other sleep disorders. When the researchers excluded people with major chronic conditions such as cancer, heart disease and high blood pressure from the analysis, the association between RLS and an increased risk of death rose to 92 percent higher than those without RLS.

"We found that the increased risk was not associated with the usual known risk factors, such as older age, being overweight, lack of sleep, smoking, being physically inactive and having an unhealthy diet," Gao said. "The increased mortality in RLS was more frequently associated with respiratory disease, endocrine disease, nutritional/metabolic disease and immunological disorders. Through research, we need to pinpoint why and how RLS leads to this possible higher risk of dying early."

Although RLS can occur in children, the study did not assess whether there was a long-term risk in this population.

add to favorites email to friend print save as pdf

Related Stories

The protein profile of restless leg syndrome

Jun 06, 2013

A protein profile of people with restless leg syndrome (RLS), identifies factors behind disrupted sleep, cardiovascular dysfunction and pain finds research in BioMed Central's open access journal Fluids and Barriers of th ...

Recommended for you

Brain's dynamic duel underlies win-win choices

7 hours ago

People choosing between two or more equally positive outcomes experience paradoxical feelings of pleasure and anxiety, feelings associated with activity in different regions of the brain, according to research ...

ALS disease is rare, 1st US count finds

8 hours ago

(AP)—The U.S. government has issued its first national estimate for amyotrophic lateral sclerosis, or ALS, confirming the devastating disease is rare.

Study links enzyme to autistic behaviors

Jul 23, 2014

Fragile X syndrome (FXS) is a genetic disorder that causes obsessive-compulsive and repetitive behaviors, and other behaviors on the autistic spectrum, as well as cognitive deficits. It is the most common ...

User comments