Improving systematic reviews of animal studies will help translational medicine

Many new developments and initiatives have been introduced to improve the quality and translational value of animal research, and must continue with support from the wider scientific community. These are the conclusions of a new article in PLOS Medicine this week by Carlijn Hooijmans and colleagues from the Radboud University Nijmegen Medical Centre, Netherlands, who summarize these new developments.

Focusing on the quality of study conduct, reporting, and replication; systematic reviews and meta-analyses; and study registration, , and data sharing, the authors argue that systematic reviews of animal studies should be conducted routinely. Funding agencies should subsidize systematic reviews, not simply for transparency, but also to avoid waste of financial resources and unnecessary duplication of animal studies, they say, and an international register for animal studies should be established and funded.

"Improving the quality and translation of requires co-operation from the wider scientific community, journals, researchers, regulators, funding bodies, peer reviewers and patients," conclude the authors.

More information: Hooijmans CR, Ritskes-Hoitinga M (2013) Progress in Using Systematic Reviews of Animal Studies to Improve Translational Research. PLoS Med 10(7): e1001482. doi:10.1371/journal.pmed.1001482

add to favorites email to friend print save as pdf

Related Stories

How should systematic reviews consider evidence on harms?

May 03, 2011

Systematic reviews that attempt to assess the risk of harms (adverse effects) associated with specific therapies should consider a broad range of study designs, including both systematic reviews and observational studies. ...

Recommended for you

Simulation-based training improves endoscopy execution

Oct 18, 2014

(HealthDay)—Simulation-based training (SBT) improves clinicians' performance of gastrointestinal endoscopy in both test settings and clinical practice, according to research published in the October issue ...

Data sharing in pharmaceutical industry shows progress

Oct 16, 2014

To enhance the transparency of clinical trials for new drugs, a number of pharmaceutical firms have begun sharing data with investigators outside their own companies. Brian L. Strom, chancellor of Rutgers Biomedical and Health ...

Swiss drug maker Roche posts flat 3Q sales

Oct 16, 2014

(AP)—Swiss drugmaker Roche Holding AG has reported "stable" or flat sales for the first nine months of 2013 but says the results show strong demand for its cancer drugs and emerging new products.

User comments