Central adiposity may blunt metabolism, worsen weight gain

Central adiposity may blunt metabolism, worsen weight gain

(HealthDay)—In those with body mass index (BMI) greater than 29 kg/m2, awake and fed thermogenesis is reduced, and this change in energy balance predicts future weight gain, according to research published in the December issue of Diabetes.

Paolo Piaggi, M.D., of the National Institutes of Health in Phoenix, and colleagues measured whole-room 24-hour energy expenditure (EE) in 509 healthy subjects (368 Native Americans and 141 whites) who consumed a eucaloric diet, calculated awake and fed thermogenesis (AFT), then used follow-up data for 290 Native Americans to assess the association between AFT and weight change.

The researchers found that AFT accounted for approximately 10 percent of 24-hour EE and was inversely related to age and fasting glucose concentration. Energy intake was the main factor that determined AFT. For individuals with BMI greater than 29 kg/m², AFT was inversely related to BMI. After accounting for covariates, the residual variance of AFT predicted future weight change, but only in those with BMI greater than 29 kg/m².

"AFT may influence daily , is reduced in obese individuals, and predicts future weight gain in these subjects," the authors write. "Once central adiposity develops, a blunting of AFT may occur that then contributes to further weight gain."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Gene variants linked to obesity

date Aug 09, 2013

(HealthDay)—Variants of a gene are associated with overweight and obesity in psychiatric patients taking drugs that induce weight gain, as well in the general population, according to a study published ...

Recommended for you

New measures identified for newborn care in Uganda

date 11 minutes ago

In Uganda, child mortality rates are improving, but progress is slower for deaths occurring in the first four weeks of life, or the newborn period, and for stillbirths. But recent evidence from local researchers ...

Should men cut back on their soy intake?

date 2 hours ago

Recently, a friend called my husband to inquire about the risks for men in consuming too much soy milk. He had read an article that described how one individual's plight led him down the path of breast enlargement, and was ...

Probing Question: What is umami?

date 3 hours ago

The next time you're at a dinner party and want to spice up the conversation, you might compliment the hosts on their umami-rich appetizers. Then wait a moment until someone invariably asks, "What's umami?"

Will the Affordable Care Act eliminate health disparities?

date 4 hours ago

Massachusetts' health reform may be a crystal ball for researchers and policymakers in forecasting the potential impact of the Affordable Care Act. Many see the ACA as the backbone of efforts toward closing the nation's health ...

Experts question election pledges on GP access

date 16 hours ago

As the general election in the UK approaches, experts writing in The BMJ this week question whether the party promises on access to general practice are likely to be achievable.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.