Comorbidities, meds factor into recurrent syncope

Comorbidities, meds factor into recurrent syncope

(HealthDay)—Certain comorbidities, age, gender, and use of multiple medications that cause orthostatic hypotension are associated with increased risk of recurrent syncope, according to research published in the Nov. 15 issue of The American Journal of Cardiology.

Martin Huth Ruwald, M.D., Ph.D., of Gentofte Hospital in Hellerup, Denmark, and colleagues analyzed data from 2001 to 2009 for patients older than 50 years, who were discharged after an initial episode of syncope, to assess the predictive factors for recurrent syncope.

The researchers found that patients with syncope who were 85 years or older were more often women (65 versus 47 percent) and, in general, had more non-cardiovascular comorbid conditions. The prevalence of cardiovascular comorbidities was distributed across age groups. Baseline predictors that were significantly associated with recurrent syncope included (hazard ratio [HR], 1.48), impaired renal function (HR, 1.34), atrioventricular or left bundle branch block (HR, 1.32), male gender (HR, 1.18), chronic obstructive pulmonary disorder (HR, 1.10), heart failure (HR, 1.10), atrial fibrillation (HR, 1.09), age per five-year increment (HR, 1.09), and each increase in medications that cause orthostatic hypotension (HR, 1.06).

"The use of multiple orthostatic medications additively increased the risk of recurrences, representing a need for strategies to reduce unnecessary polypharmacy," the authors write.

One author received independent research scholarship funds from the Novo Nordisk Foundation.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Risk of comorbidities up with hypoglycemia in T2DM

Apr 08, 2013

(HealthDay)—For patients with type 2 diabetes, hypoglycemia, regardless of its severity, correlates with a significantly increased risk of cardiovascular events, all-cause hospitalization, and mortality, ...

Recommended for you

Gene variant raises risk for aortic tear and rupture

Apr 17, 2014

Researchers from Yale School of Medicine and Celera Diagnostics have confirmed the significance of a genetic variant that substantially increases the risk of a frequently fatal thoracic aortic dissection or full rupture. ...

Considerable variation in CT use in ischemic stroke

Apr 17, 2014

(HealthDay)—For patients with ischemic stroke there is considerable variation in the rates of high-intensity computed tomography (CT) use, according to a study published online April 8 in Circulation: Ca ...

Beating the clock for ischemic stroke sufferers

Apr 17, 2014

A ground-breaking computer technology raises hope for people struck by ischemic stroke, which is a very common kind of stroke accounting for over 80 per cent of overall stroke cases. Developed by research experts at The Hong ...

User comments