French firm starts human trials of artificial heart

French biomedical firm Carmat said on Friday it had begun the first human trial of its prototype artificial heart, which aims at overcoming shortages of organs available for transplant.

The implant operation, which took place on Wednesday at the Georges Pompidou Hospital in Paris, "went satisfactorily," it said in a statement.

The patient, whom it did not name, is in intensive care, "is conscious and speaking to relatives," Carmat said, adding that it was too early to draw wider conclusions about the operation.

Artificial hearts have been in use for many years as a temporary fix for patients with chronic heart problems.

Tens of thousands of people with hearts damaged by disease or a heart attack die each year because of a lack of a donor.

The Carmat product aims at providing a longer-term solution to bridge the wait and enable hospitalised patients to return home and maybe even resume work.

A self-contained unit implanted in the patient's chest, it uses soft "biomaterials" and an array of sensors, rather than a pump, to mimic the contractions of the heart.

The goal is to lessen the risk of blood clots and rejection by the immune system.

Power comes from an external source or wearable lithium batteries.

The company was authorised in September by French health watchdogs to carry out four trials in three hospitals after tests on animals.

The 900-gramme (31-ounce) device is the outcome of a years-long collaboration between cardiac surgeon Alain Carpentier and the European aerospace giant EADS.

Nearly 100,000 people in Europe and the United States are in need of a heart transplant, according to Carmat.

The price of the heart is estimated at between 140,000 and 180,000 euros ($190,000 and $244,000).

Phase I of the trial, on the small group of volunteers in terminal condition, will assess survival one month after the operation, or earlier if the patient receives a natural heart.

If all goes well, a second phase, conducted among a group of about 20 patients, will look at efficacy—quality of life, comfort and side effects—as well as safety.

A US rival to Carmat, an artificial heart called AbioCor made the biotech firm Abiomed, is authorised in the United States for patients with end-stage heart-failure or life expectancy of less than 30 days, who are not eligible for a natural heart plant and have no other viable treatment options.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Diet affects men's and women's gut microbes differently

8 hours ago

The microbes living in the guts of males and females react differently to diet, even when the diets are identical, according to a study by scientists from The University of Texas at Austin and six other institutions published ...

Researchers explore what happens when heart cells fail

9 hours ago

Through a grant from the United States-Israel Binational Science Foundation, Biomedical Engineering Associate Professor Naomi Chesler will embark upon a new collaborative research project to better understand ...

Stem cells from nerves form teeth

11 hours ago

Researchers at Karolinska Institutet in Sweden have discovered that stem cells inside the soft tissues of the tooth come from an unexpected source, namely nerves. These findings are now being published in the journal Nature and co ...

User comments