Isotonic fluids safer for pediatric maintenance IV therapy

Isotonic fluids safer for pediatric maintenance IV therapy
For children requiring maintenance intravenous fluids, isotonic fluids are safer than hypotonic fluids in terms of plasma sodium levels, according to a meta-analysis published online Dec. 30 in Pediatrics.

(HealthDay)—For children requiring maintenance intravenous (IV) fluids, isotonic fluids are safer than hypotonic fluids in terms of plasma sodium (pNa) levels, according to a meta-analysis published online Dec. 30 in Pediatrics.

Jingjing Wang, M.D., from the Second Affiliated Hospital of Medical School of Xi'an Jiaotong University in China, and colleagues conducted a systematic literature review and assessed evidence from 10 to compare the safety of isotonic versus hypotonic IV maintenance in hospitalized . A meta-analysis was conducted to assess the risks of developing hyponatremia (pNa < 136 mmol/L), severe hyponatremia (pNa < 130 mmol/L), and hypernatremia (pNa > 145 mmol/L).

The researchers found that the risks for developing hyponatremia and severe hyponatremia were significantly increased with hypotonic IV fluids (relative risks, 2.24 and 5.29, respectively). Children who received hypotonic fluids experienced a significantly greater fall in pNa than those who received isotonic fluids (−3.49 mmol/L). The risk of hypernatremia was not significantly different between the intervention groups (relative risk, 0.73; 95 percent confidence interval, 0.22 to 2.48).

"Overall, isotonic fluids are safer than hypotonic fluids in hospitalized children requiring maintenance IV fluid therapy in terms of pNa levels," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

IV fluids used by NHS responsible for unnecessary deaths

Feb 27, 2013

Starch-based intravenous (IV) fluids used by the NHS to treat seriously ill patients are causing unnecessary deaths, according to a new Cochrane systematic review by researchers at the London School of Hygiene & Tropical Medici ...

Restricting food and fluids during labor is unwarranted

Aug 23, 2013

Despite the longstanding, widespread practice of restricting women's food and fluid intake during labor, a large-scale analysis in The Cochrane Library finds no need for these restrictions and supports women ...

Maternal IV fluids linked to newborns' weight loss

Aug 15, 2011

A newborn baby's weight loss is often used to determine how well a baby is breastfeeding, and concern about a baby which loses too much weight may result in supplementing breastfeeding with formula. However, many women receive ...

Recommended for you

Second bird flu case confirmed in Canada

6 hours ago

The husband of a Canadian who was diagnosed earlier this week with bird flu after returning from a trip to China has also tested positive for the virus, health officials said Friday.

What exactly is coronavirus?

13 hours ago

The conflicts in Syria and Iraq are straining public health systems and public health efforts meant to prevent and detect the spread of infectious diseases. This is generating a "perfect storm" of conditions for outbreaks. Among the infections raising concern is Middle East Respiratory Syndrome, caused by a type of coronavirus, which emerged in 2012. ...

Scientists find Ebola virus is mutating

13 hours ago

(Medical Xpress)—Researchers working at Institut Pasteur in France have found that the Ebola virus is mutating "a lot" causing concern in the African countries where the virus has killed over eight thous ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.