Isotonic fluids safer for pediatric maintenance IV therapy

January 3, 2014
Isotonic fluids safer for pediatric maintenance IV therapy
For children requiring maintenance intravenous fluids, isotonic fluids are safer than hypotonic fluids in terms of plasma sodium levels, according to a meta-analysis published online Dec. 30 in Pediatrics.

(HealthDay)—For children requiring maintenance intravenous (IV) fluids, isotonic fluids are safer than hypotonic fluids in terms of plasma sodium (pNa) levels, according to a meta-analysis published online Dec. 30 in Pediatrics.

Jingjing Wang, M.D., from the Second Affiliated Hospital of Medical School of Xi'an Jiaotong University in China, and colleagues conducted a systematic literature review and assessed evidence from 10 to compare the safety of isotonic versus hypotonic IV maintenance in hospitalized . A meta-analysis was conducted to assess the risks of developing hyponatremia (pNa < 136 mmol/L), severe hyponatremia (pNa < 130 mmol/L), and hypernatremia (pNa > 145 mmol/L).

The researchers found that the risks for developing hyponatremia and severe hyponatremia were significantly increased with hypotonic IV fluids (relative risks, 2.24 and 5.29, respectively). Children who received hypotonic fluids experienced a significantly greater fall in pNa than those who received isotonic fluids (−3.49 mmol/L). The risk of hypernatremia was not significantly different between the intervention groups (relative risk, 0.73; 95 percent confidence interval, 0.22 to 2.48).

"Overall, isotonic fluids are safer than hypotonic fluids in hospitalized children requiring maintenance IV fluid therapy in terms of pNa levels," the authors write.

Explore further: IV fluids used by NHS responsible for unnecessary deaths

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

IV fluids used by NHS responsible for unnecessary deaths

February 27, 2013

Starch-based intravenous (IV) fluids used by the NHS to treat seriously ill patients are causing unnecessary deaths, according to a new Cochrane systematic review by researchers at the London School of Hygiene & Tropical ...

Restricting food and fluids during labor is unwarranted

August 23, 2013

Despite the longstanding, widespread practice of restricting women's food and fluid intake during labor, a large-scale analysis in The Cochrane Library finds no need for these restrictions and supports women eating and drinking ...

Maternal IV fluids linked to newborns' weight loss

August 15, 2011

A newborn baby's weight loss is often used to determine how well a baby is breastfeeding, and concern about a baby which loses too much weight may result in supplementing breastfeeding with formula. However, many women receive ...

Recommended for you

Researchers discover rare flu-thwarting mutation

September 29, 2016

A rare and improbable mutation in a protein encoded by an influenza virus renders the virus defenseless against the body's immune system. This University of Rochester Medical Center discovery could provide a new strategy ...

Utah man may have contracted Zika from dying father's tears

September 29, 2016

A Utah man who mysteriously contracted Zika from his infected father may have got it by touching his dad's tears or sweat with his bare hands, according to new research unveiled Wednesday that found the unusual transmission ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.