Novel blood screen reveals risk of dying among healthy people

February 25, 2014

Researchers from Finland and Estonia have discovered novel biological markers that are strongly indicative of risk of dying from any disease within the near future. Blood samples from over 17 000 generally healthy people were screened for more than a hundred different biomolecules. The health status of these study volunteers was followed for several years. The researchers looked for measures in the blood that could reflect who had died within the following 5 years after the blood sample was taken. In a study published in PLOS Medicine today they describe identification of four such biomarkers of death.

The identified biomarkers were albumin, alpha-1-acid glycoprotein, citrate and the size of very-low-density lipoprotein particles. Of these, albumin was the only one previously linked with mortality. All these molecules are normally present in everyone's blood, but it is the amount of these molecules that was shown to be important.

The novel biomarkers helped to detect individuals at much higher risk of dying during the five-year follow-up. The measures were independent of well-known risk factors such as age, smoking, drinking, obesity, and cholesterol. The result did not change even when only apparently healthy persons were examined.

What is especially interesting is that these biomarkers reflect the risk for dying from very different types of diseases such as or cancer. They seem to be signs of a general frailty in the body. Next we aim to study whether some kind of connecting factor between these can be identified, says Dr. Johannes Kettunen.

We believe that in the future these measures can be used to identify people who appear healthy but in fact have serious underlying illnesses and guide them to proper treatment. More studies are, however, needed before these findings can be implemented in clinical practice, Dr. Kettunen continues.

More information: PLOS Medicine 2014;11:e1001606, DOI: 10.1371/journal.pmed.1001606

Related Stories

Schizophrenia enters the molecular diagnostics era

February 12, 2014

With a drop of blood and some laboratory analyses, doctors have been able to tell patients whether they suffer from diabetes or some sort of cancer. Measuring changes in the cells or molecules of human tissues or fluids, ...

Recommended for you

New treatment options for a fatal leukemia

July 27, 2015

In industrialized countries like in Europe, acute lymphoblastic leukemia is the most common form of cancer in children. An international research consortium lead by pediatric oncologists from the Universities of Zurich and ...

Exciting results from cancer immunoagent study

July 20, 2015

(Medical Xpress)—Cancer therapies have improved incrementally over the years, but cancer treatment largely remains analogous to forest fire suppression, in which the spread of fire is contained with deliberate controlled ...

Lymphomas tied to metabolic disruption

July 17, 2015

Researchers from the School of Medicine at The University of Texas Health Science Center at San Antonio have found evidence that directly links disrupted metabolism (energy production in cells) to a common and often fatal ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.