Type 1 diabetes: Vitamin D deficiency occurs in an early stage

Vitamin D is known as a major regulator of calcium levels and bone metabolism. Furthermore, it also influences the immune system. Previous studies have shown that patients with recently diagnosed type 1 diabetes have significantly lower vitamin D levels.

Scientists from the Institute of Diabetes Research (IDF) and the Helmholtz Zentrum München, a member of the German Center for Diabetes Research (DZD), as well as from the Diabetes Research Group at the Technische Universität München (TUM) examined whether a vitamin D deficiency occurs during an early stage of , defined by the presence of multiple diabetes-specific autoantibodies. Furthermore they also determined whether vitamin D deficiency influences the progression to type 1 diabetes in children with multiple islet autoantibodies.

Vitamin D deficiency already exists in prediabetes

Children who had not yet developed clinical type 1 diabetes but who have multiple positive autoantibodies in their blood were found to have lower vitamin D levels than children without diabetes-specific autoantibodies. Interestingly, the differences in vitamin D levels were most prevalent in the summer months. These results were obtained from the BABYDIET, BABYDIAB, TEENDIAB and DIMELLI* diabetes studies. The team of scientists headed by Jennifer Raab, Dr. Christiane Winkler and Professor Anette-Gabriele Ziegler compared the vitamin D measurements taken from 108 children who were tested positive for islet autoantibodies with 406 children without autoantibodies. Lower vitamin D levels were also found in 244 children who had recently been diagnosed with type 1 diabetes.

Progression of the disease remains unaffected

Prediabetes is defined as the presence of multiple islet autoantibodies. If and when the disease progresses, however, does not seem to be influenced by the vitamin D levels. Within the group of children with positive autoantibodies, a few children quickly developed type 1 diabetes – however this was independent from their vitamin D levels.

Recommendation of vitamin D supplementation at an early stage of type 1 diabetes may be considered

"Vitamin D deficiency precedes the onset of type 1 diabetes. This may be a consequence of an immune response," Professor Ziegler says. "In the case of prediabetic children, we must therefore be mindful of the risk of vitamin D deficiency and consider recommending D supplementation at an early stage of type 1 ."

add to favorites email to friend print save as pdf

Related Stories

Vitamin D deficiency may compromise immune function

Feb 25, 2014

Older individuals who are vitamin D deficient also tend to have compromised immune function, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) ...

Testing whether vitamin D delays onset of diabetes

Jan 09, 2014

Northwestern Medicine is looking for volunteers to take part in the first definitive, large-scale clinical trial to investigate if a vitamin D supplement helps to delay or prevent the onset of type 2 diabetes in adults wh ...

Can citrus ward off your risk of stroke?

Feb 14, 2014

Eating foods that contain vitamin C may reduce your risk of the most common type of hemorrhagic stroke, according to a study released today that will be presented at the American Academy of Neurology's 66th Annual Meeting ...

Recommended for you

Screening for diabetes at dental visits using oral blood

Feb 26, 2015

It is estimated that 8.1 million of the 29.1 million Americans living with diabetes are undiagnosed and many who have diabetes have poor glycemic control. Given that each year many Americans visit a dental provider but not ...

CBT, sertraline insufficient in diabetes and depression

Feb 26, 2015

(HealthDay)—For patients with diabetes and depression, improvements in depression are seen with cognitive behavioral therapy (CBT) or sertraline, with a significant advantage for sertraline, but glycemic ...

Early signs in young children predict type 1 diabetes

Feb 26, 2015

New research shows that it is possible to predict the development of type 1 diabetes. By measuring the presence of autoantibodies in the blood, it is possible to detect whether the immune system has begun to break down the ...

Daily menu plan reduces blood sugar significantly

Feb 25, 2015

A large group of people with diabetes who followed a menu plan created by University of Alberta nutrition researchers for just three months significantly reduced their blood sugar levels.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.