Early treatment with AED reduces duration of febrile seizures

New research shows that children with febrile status epilepticus (FSE) who receive earlier treatment with antiepileptic drugs (AEDs) experience a reduction in the duration of the seizure. The study published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), suggests that a standard Emergency Medical Services (EMS) treatment protocol for FSE is needed in the U.S.

While medical evidence reports that brief or simple febrile seizures are most common, up to 10% of cases are prolonged and meet the criteria for status epilepticus (SE)—a critical condition where a persistent lasts more than 30 minutes. Prior research shows that FSE accounts for 25% of all childhood SE, with more than 70% of SE cases occurring in the second year of life. Prolonged seizures place patients at risk of short-term and long-term complications, including the development of epilepsy.

"The time from the start of the seizure to treatment is crucial to improving patient outcomes," said lead author Syndi Seinfeld, DO, assistant professor, Division of Child Neurology at Children's Hospital of Richmond at Virginia Commonwealth University. "Our study is the first to examine the treatment of FSE by EMS, which currently does not have a standard therapy protocol for prolonged seizures."

The present study recruited 199 pediatric patients who were part of the FEBSTAT study—a prospective, multicenter, NIH-funded study (PI Shlomo Shinnar MD PhD at Albert Einstein College of Medicine) investigating the consequences of FSE. The , between the ages of 1 month and 6 years, had a seizure or cluster of seizures lasting more than 30 minutes. Researchers analyzed the relationship between seizure duration, treatment delay and related morbidity.

"The FEBSTAT study is designed to understand the consequences of prolonged in hopes of identifying children at greater risk of adverse outcomes and to help develop better treatments," said Brandy Fureman, Ph.D., a program director at the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health.

Findings indicate that roughly 90% (179) of children received at least one AED and more than AED was needed in 70% (140) of patients to terminate FSE. On average it was 30 minutes from the seizure onset to the time EMS or emergency department staff administered the first AED. The mean seizure time was 81 minutes for children treated prior to arrival at the emergency department and 95 minutes for those who were not.

Further analyses determined the average time to end the seizure was 38 minutes following the first AED dose. Seizure duration was 83 minutes in 48% of patients who needed respiratory support and 58 minutes for subjects not requiring respiratory support.

"Our findings clearly show that early AED initiation results in shorter seizure duration," concludes Dr. Seinfeld. "A standard FSE prior to arrival at the hospital, along with training for EMS staff, is needed across the U.S. to help improve outcomes for children with prolonged seizures."

More information: "Emergency Management of Febrile Status Epilepticus: Results of The FEBSTAT Study." Syndi Seinfeld, Shlomo Shinnar, Shumei Sun, Dale C Hesdorffer, Xiaoyan Deng, Ruth C Shinnar, Kathryn O'Hara, Douglas R Nordli Jr, L Matthew Frank, William Gallentine, Solomon L Moshé, John M Pellock and the FEBSTAT study team. Epilepsia; Published Online: February 6, 2014. DOI: 10.1111/epi.12526

add to favorites email to friend print save as pdf

Related Stories

Treatment-resistant epilepsy common in idiopathic autism

Apr 19, 2011

A new study found that treatment-resistant epilepsy (TRE) is common in idiopathic autism. Early age at the onset of seizures and delayed global development were associated with a higher frequency of resistance to antiepileptic ...

Recommended for you

Omega-3 fatty acids and vitamin D may control brain serotonin

3 hours ago

Although essential marine omega-3 fatty acids and vitamin D have been shown to improve cognitive function and behavior in the context of certain brain disorders, the underlying mechanism has been unclear. In a new paper published ...

Researchers develop method for mapping neuron clusters

6 hours ago

A team of scientists has developed a method for identifying clusters of neurons that work in concert to guide the behavior. Their findings, which appear in the journal Neuron, address a long-standing mystery about the or ...

One brain area, two planning strategies

9 hours ago

Ready to strike, the spear fisherman holds his spear above the water surface. He aims at the fish. But he is misled by the view: Due to the refraction of light on the surface, he does not see the actual location ...

Study maps extroversion types in the brain's anatomy

17 hours ago

Everyday experience and psychological studies alike tell us that there are two different types of extroverts: The gregarious "people-persons" who find reward in sharing affection and affiliation with others, ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.