Considerable sudden death in hypertrophic cardiomyopathy

April 22, 2014
Considerable sudden death in hypertrophic cardiomyopathy

(HealthDay)—Patients with hypertrophic cardiomyopathy (HC) without traditional risk factors and with no or mild symptoms have a considerable rate of sudden cardiac death, according to a study published in the May 1 issue of The American Journal of Cardiology.

Paolo Spirito, M.D., from the Ente Ospedaliero Ospedali Galliera in Genoa, Italy, and colleagues examined the risk of in a cohort of 653 with HC, without and with no or mild symptoms. Patients were followed for a median of 5.3 years.

The researchers found that 5.4 percent of the participants died of HC-related causes during follow-up. The mean age of death was 46 years for patients who died suddenly, 66 years for patients who died of , and 72 years for patients who died of stroke. For , heart failure death, and stroke-related death, the event rate was 0.6, 0.2, and 0.1 percent per year, respectively. There was an inverse and independent correlation for sudden death risk with age; heart failure and stroke risk correlated directly with age (P = 0.020). Sudden death risk was 5.9 percent at 10 years after the initial evaluation, with patients with normal left atrial dimension (≤40 mm) having the lowest risk (0.3 percent).

"In conclusion, in our patients with HC with no conventional risk factors and no or mild symptoms, the rate of sudden death proved to be more common than expected (0.6 percent per year)," the authors write.

One author disclosed financial ties to GeneDx and Medtronic.

Explore further: Nocturnal respiratory rate predicts cardiac risk after MI

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Nocturnal respiratory rate predicts cardiac risk after MI

March 10, 2014

(HealthDay)—Among survivors of acute myocardial infarction (MI), nocturnal respiratory rate (NRR) is significantly associated with cardiac mortality, particularly non-sudden cardiac death, according to research published ...

Recommended for you

Optimism may reduce risk of dying prematurely among women

December 7, 2016

Having an optimistic outlook on life—a general expectation that good things will happen—may help people live longer, according to a new study from Harvard T.H. Chan School of Public Health. The study found that women ...

New discovery at heart of healthy cereals

December 6, 2016

A new discovery at the University of Queensland could help reduce heart disease and boost nutrition security – the access to balanced nourishment - globally.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.