Considerable sudden death in hypertrophic cardiomyopathy

Considerable sudden death in hypertrophic cardiomyopathy

(HealthDay)—Patients with hypertrophic cardiomyopathy (HC) without traditional risk factors and with no or mild symptoms have a considerable rate of sudden cardiac death, according to a study published in the May 1 issue of The American Journal of Cardiology.

Paolo Spirito, M.D., from the Ente Ospedaliero Ospedali Galliera in Genoa, Italy, and colleagues examined the risk of in a cohort of 653 with HC, without and with no or mild symptoms. Patients were followed for a median of 5.3 years.

The researchers found that 5.4 percent of the participants died of HC-related causes during follow-up. The mean age of death was 46 years for patients who died suddenly, 66 years for patients who died of , and 72 years for patients who died of stroke. For , heart failure death, and stroke-related death, the event rate was 0.6, 0.2, and 0.1 percent per year, respectively. There was an inverse and independent correlation for sudden death risk with age; heart failure and stroke risk correlated directly with age (P = 0.020). Sudden death risk was 5.9 percent at 10 years after the initial evaluation, with patients with normal left atrial dimension (≤40 mm) having the lowest risk (0.3 percent).

"In conclusion, in our patients with HC with no conventional risk factors and no or mild symptoms, the rate of sudden death proved to be more common than expected (0.6 percent per year)," the authors write.

One author disclosed financial ties to GeneDx and Medtronic.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Vitamin K antagonist plus clopidogrel feasible for PCI

Sep 19, 2014

(HealthDay)—Vitamin K antagonists (VKA) combined with clopidogrel may be a better alternative to triple anticoagulant therapy in patients on long-term VKA undergoing percutaneous coronary intervention (PCI) ...

How pneumonia bacteria can compromise heart health

Sep 19, 2014

Bacterial pneumonia in adults carries an elevated risk for adverse cardiac events (such as heart failure, arrhythmias, and heart attacks) that contribute substantially to mortality—but how the heart is ...

An autoimmune response may contribute to hypertension

Sep 17, 2014

High blood pressure is a major risk factor for heart attack, stroke, chronic heart failure, and kidney disease. Inflammation is thought to promote the development of high blood pressure, though it is not clear what triggers ...

User comments