Vitamin D supplementation may be beneficial in depression

April 7, 2014
Vitamin D supplementation may be beneficial in depression

(HealthDay)—Vitamin D supplementation has no overall effect on depressive symptoms, but may have a significant effect for those with clinically significant depression, according to a review published online March 14 in Psychosomatic Medicine.

Jonathan A. Shaffer, Ph.D., from the Columbia University Medical Center in New York City, and colleagues conducted a systematic review to identify randomized trials that compared the effect of vitamin D supplementation with a control condition on depression or . Seven trials, involving 3,191 participants, were included in the analyses.

The researchers found that despite considerable heterogeneity there was no overall effect for vitamin D supplementation on depressive symptoms (standardized mean difference [SMD], −0.14; P = 0.16). For participants with clinically significant depressive symptoms or , vitamin D supplementation had a moderate, statistically significant effect (two studies: SMD, −0.60; P = 0.046), while the effect was small and nonsignificant for those without clinically significant depression (five studies: SMD, −0.04; P = 0.61). The risk of bias was unclear or high in most trials.

"Vitamin D supplementation may be effective for reducing depressive symptoms in patients with clinically significant depression; however, further high quality research is needed," the authors write.

Explore further: Lack of nutrients and metabolic syndrome linked to different subtypes of depression

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

When it comes to replicating studies, context matters

May 23, 2016

Contextual factors, such as the race of participants in an experiment or the geography of where the experiment was run, can reduce the likelihood of replicating psychological studies, a team of New York University researchers ...

Hacking memory to follow through with intentions

May 23, 2016

Whether it's paying the electric bill or taking the clothes out of the dryer, there are many daily tasks that we fully intend to complete and then promptly forget about. New research suggests that linking these tasks to distinctive ...

How depression and antidepressant drugs work

May 18, 2016

New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease and brings together two hypotheses for the cause of depression. The research, led by Bernhard Lüscher, professor ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.