DDW: Endoscopic L-menthol spray ups colon polyp detection

DDW: endoscopic L-menthol spray ups colon polyp detection

(HealthDay)—For patients undergoing colonoscopy, L-menthol sprayed directly onto the colonic mucosa improves the adenoma detection rate, according to a study presented at the annual Digestive Disease Week, held from May 3 to 6 in Chicago.

Noting that L-menthol has suppressed gastric peristalsis in , Ken Inoue, M.D., from the Kyoto Prefectural University of Medicine in Japan, and colleagues examined its efficacy by endoscopic spray in . Two hundred twenty-six patients were randomized to receive 320 mg L-menthol (118 patients) or placebo (108 patients), which was directly sprayed on the cecum. If and when intestinal peristalsis occurred, L-menthol was sprayed again in the L-menthol group.

The researchers found that in the L-menthol group the adenoma detection rate was significantly higher than in the placebo group (60.2 versus 42.6; P = 0.0083). In the L-menthol group, a significantly higher proportion of patients had no peristalsis after treatment, compared with the placebo group (71.2 versus 30.9 percent; P < 0.0001). The peristaltic scores were significantly lower for L-menthol-treated than before treatment (P < 0.0001 after treatment). In the , the scores were not significantly different before and after treatment. No adverse effects were observed in either group.

"The results suggest that the suppression of colonic peristalsis by L-menthol sprayed directly onto the colonic mucosa improves the adenoma detection rate," the authors write.

More information: Abstract
More Information

add to favorites email to friend print save as pdf

Related Stories

US: Menthol cigarettes likely pose health risk

Jul 23, 2013

(AP)—A Food and Drug Administration review concludes that menthol cigarettes likely pose a greater public health risk than regular cigarettes but does not make a recommendation on whether to limit or ban the minty smokes—one ...

Recommended for you

High prevalence of HCV in baby boomers presenting to ER

40 minutes ago

(HealthDay)—The prevalence of unrecognized chronic hepatitis C virus (HCV) is high among baby boomers presenting to the emergency department, according to a study published online Jan. 28 in Hepatology.

The hidden burden of dengue fever in West Africa

1 hour ago

Misdiagnosis of febrile illnesses as malaria is a continuing problem in Africa. A new study shows that in Ghana, dengue fever is circulating in urban areas and going undiagnosed. The authors of the study hope to use the findings ...

Teenager with stroke symptoms actually had Lyme disease

1 hour ago

A Swiss teenager, recently returned home from a discotheque, came to the emergency department with classic sudden symptoms of stroke, only to be diagnosed with Lyme disease. The highly unusual case presentation was published ...

Understanding lung disease in aboriginal Australians

2 hours ago

A new study has confirmed that Aboriginal Australians have low forced vital capacity—or the amount of air that can be forcibly exhaled from the lungs after taking the deepest breath possible. The finding may account for ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.