Researchers examine intersection of aging, chronic disease

A new collection of articles appearing in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences examine how the basic biology of aging drives chronic disease. Together, they highlight the value of the emerging field of geroscience, which uses an integrated approach to the study of diseases and disability associated with growing older.

Geroscience seeks to bridge the divide between studies of aging and studies of chronic disease, with the hope of understanding their complex relationship and pointing the way to novel interventions for disease, frailty, and disability.

The included articles were inspired by the inaugural summit convened by the National Institutes of Health's Trans-NIH Geroscience Interest Group. Under the continued theme of "Advances in Geroscience: Impact on Healthspan and Chronic Disease," these pieces focus on seven mechanisms that intersect aging and chronic disease pathways: inflammation, adaptation to stress, epigenetics, metabolism, macromolecular damage, proteostasis, and stem cells and regeneration.

"Although we can reasonably expect to live longer today than past generations did,the age-related disease burden we will have to confront has not changed," state the authors of the lead article. "With the proportion of older people among the global population being now higher than at any time in history and still expanding, maintain health into old has become a new and urgent frontier for modern medicine."

Each entry in the article collection uses the foundational concepts of geroscience to understand basic cellular and molecular underpinnings of aging as a principal risk factor for a variety of ; explore common mechanisms governing relationships between aging and chronic diseases; and identify new pathways for research collaboration.

Provided by The Gerontological Society of America

1 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Edible flowers may inhibit chronic diseases

Apr 21, 2014

A new study in the Journal of Food Science, published by the Institute of Food Technologists (IFT), found that common edible flowers in China are rich in phenolics and have excellent antioxidant capacity.

Defining the new normal in aging

Feb 27, 2013

Diana McIntyre approaches her 80th birthday later this year with the same energy and zest for life of friends decades her junior. Aside from back surgery years ago, she's never been sick and, through a busy volunteer schedule, ...

Recommended for you

Before you go... are you in denial about death?

2 hours ago

For most of us, death conjures up strong feelings. We project all kinds of fears onto it. We worry about it, dismiss it, laugh it off, push it aside or don't think about it at all. Until we have to. Of course, ...

UK court to rule on landmark 'pregnancy crime' case

3 hours ago

A British court is to rule on whether a woman committed a "crime of violence" against her child by drinking heavily during pregnancy, in a case that has raised concerns about criminalising mothers.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.