Can vitamin D slow heart complications from diabetes?

by Jim Dryden
Can vitamin D slow heart complications from diabetes?
Carlos Bernal-Mizrachi, MD, works with diabetes patient Helen Randall to see whether treatment with vitamin D may help lower her risk for coronary heart disease.

(Medical Xpress)—Researchers at Washington University School of Medicine in St. Louis are evaluating whether vitamin D can slow the development of cardiovascular problems in African-Americans with diabetes. They are more likely to die from cardiovascular disease than Caucasians with diabetes.

The researchers are seeking to enroll about 90 African-Americans who are 45 to 80 years old and have type 2 diabetes. Study volunteers must not have heart disease or have suffered a stroke.

"Cardiovascular disease is a major health problem and cause of mortality in African-Americans," said Carlos Bernal-Mizrachi, MD, the study's principal investigator. "Compared to Caucasians, African-Americans suffer disproportionately from type 2 diabetes and heart disease."

Nationally, African-Americans with diabetes are 36 percent more likely than Caucasians with diabetes to die of cardiovascular disease. In past studies, Bernal-Mizrachi has found that low levels of vitamin D can double the risk of in patients with . His research also shows that blood vessels near the heart are less likely to clog in people who get adequate levels of the key vitamin.

Study volunteers will be screened at the School of Medicine to determine their vitamin D status. Those with low vitamin D levels will be asked to return for a second assessment, during which investigators will evaluate participants' risk for by measuring electrolyte levels, kidney function, blood cell counts, average and cholesterol levels.

This video is not supported by your browser at this time.
Credit: Washington University School of Medicine in St. Louis

"In general, vitamin D deficiency is more common among African-Americans, and that may help explain why they are so much more likely than Caucasians to have severe cardiovascular complications related to diabetes," said Bernal-Mizrachi, associate professor of medicine and of cell biology and physiology.

Volunteers who meet the study's criteria will be randomly assigned to one of two groups. Those in the first group will take 600 international units of vitamin D daily to try to raise their levels of the vitamin to the standard recommended for good health. Participants in the second study group will take 4,000 international units of the vitamin daily.

Subjects will be evaluated about every two months to measure blood sugar levels, hypertension, heart function and various markers of inflammation—all risk factors for .

"Compared to other potential interventions, vitamin D is very inexpensive and doesn't have many known side effects," said Bernal-Mizrachi. "We believe vitamin D could have a very big impact if the study shows that it can prevent or delay heart problems in African-Americans with ."

add to favorites email to friend print save as pdf

Related Stories

Vitamin D may prevent clogged arteries in diabetics

Nov 13, 2012

People with diabetes often develop clogged arteries that cause heart disease, and new research at Washington University School of Medicine in St. Louis suggests that low vitamin D levels are to blame.

Type 1 diabetes: Vitamin D deficiency occurs in an early stage

Feb 27, 2014

Vitamin D is known as a major regulator of calcium levels and bone metabolism. Furthermore, it also influences the immune system. Previous studies have shown that patients with recently diagnosed type 1 diabetes have significantly ...

Testing whether vitamin D delays onset of diabetes

Jan 09, 2014

Northwestern Medicine is looking for volunteers to take part in the first definitive, large-scale clinical trial to investigate if a vitamin D supplement helps to delay or prevent the onset of type 2 diabetes in adults wh ...

Recommended for you

Diabetes and Thanksgiving can live in harmony

Nov 25, 2014

As you may know, November is National Diabetes Month. If you, a loved one, or a Thanksgiving guest have diabetes or prediabetes, this column is dedicated to you, as you may be wondering how to enjoy one of the most food-laden ...

Does a yogurt a day keep diabetes away?

Nov 24, 2014

A high intake of yogurt has been found to be associated with a lower risk of developing type 2 diabetes, according to research published in open access journal BMC Medicine. This highlights the importance of hav ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.