Risk factors for chronic kidney disease are present decades before diagnosis

June 26, 2014

Risk factors for chronic kidney disease (CKD) are present and identifiable 30 years before diagnosis, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest avenues for future research to determine whether certain early interventions can prevent future kidney disease.

Approximately 60 million people globally have CKD. Caroline S. Fox, MD MPH, Gearoid McMahon, MB, BCh (National Heart Lung and Blood Institute's Framingham Heart Study and the Center for Population Studies), and their colleagues investigated whether CKD risk factors might be present decades before the diagnosis of CKD. "One of the benefits of the Framingham Heart Study is that we have a very long duration of follow-up. As a result, we are able to look far back in time prior to when individuals develop a disease to examine their risk factors," said Dr. Fox.

The researchers identified 441 new cases of CKD among participants of the Framingham Heart Study, and they matched them with 882 controls who did not develop CKD. Those who ultimately developed CKD were 76% more likely to have had hypertension, 71% more likely to have been obese, and 43% more likely to have had higher triglycerides 30 years before CKD diagnosis. They were also 38% more likely to have had hypertension, 35% more likely to have had higher triglyceride levels, and nearly 3-times more likely to have had diabetes 20 years before CKD . The more risk factors an individual had in the past, the more likely they were to develop CKD.

"This research shows that these risk factors are present long before the disease is diagnosed. This is important because it suggests that we should be addressing these earlier in life to potentially prevent future disease," said Dr. McMahon.

Explore further: Prenatal risk factors may put children at risk of developing kidney disease

More information: The article, entitled "Mid-Adulthood Risk Factor Profiles for CKD," will appear online at jasn.asnjournals.org/ on June 26, 2014.

Related Stories

Nonalcoholic fatty liver disease linked to CKD in T1DM

April 9, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published online April 2 in ...

Recommended for you

Zika virus infection alters human and viral RNA

October 20, 2016

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. These modifications—chemical tags known as ...

Food-poisoning bacteria may be behind Crohn's disease

October 19, 2016

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.

Neurodevelopmental model of Zika may provide rapid answers

October 19, 2016

A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos similar to microcephaly—a ...

Scientists uncover new facets of Zika-related birth defects

October 17, 2016

In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute (TSRI) have elucidated how the virus attacks the brains of newborns, ...

Ebola drug ZMapp may help, but is not a miracle cure

October 13, 2016

ZMapp, once touted as a miraculous "secret serum" against the deadly Ebola virus, has shown some success but fell short of the bar for effectiveness in a clinical trial, researchers said Wednesday.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.