Meta-analysis confirms serum 25(OH)D, mortality link

Meta-analysis confirms serum 25(OH)D, mortality link

(HealthDay)—Serum 25-hydroxyvitamin (25[OH]D) levels are associated with all-cause and cardiovascular mortality, according to a meta-analysis published online June 17 in BMJ.

Ben Schöttker, Ph.D., from the German Cancer Research Center in Heidelberg, and colleagues conducted a meta-analysis of individual participant data to examine the correlation between 25(OH)D and mortality. Participants included 26,018 men and women, aged 50 to 79 years, from the general population in Europe and the United States, enrolled in eight prospective cohort studies.

The researchers found that there was strong variation in 25(OH)D concentrations by season, country, and sex. A total of 6,695 participants died during follow-up, including 2,624 of cardiovascular diseases and 2,227 of cancer. For all-cause mortality, the pooled risk ratio was 1.57 comparing the bottom with the top quintile of 25(OH)D. Risk ratios of similar magnitude to that of all-cause mortality were seen for for individuals with and without a history of at baseline. For , there was an association only for individuals with a history of cancer (risk ratio, 1.70). Curvilinear, inverse dose-response curves were seen for these correlations based on analyses using all quintiles. In most meta-analyses, heterogeneity was low.

"Results from a long-term addressing longevity are being awaited before vitamin D supplementation can be recommended in most individuals with low 25(OH)D levels," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Vitamin D may play an important role in cancer prognosis

date Jun 17, 2014

Researchers have found that people with very low levels of vitamin D appear to be at higher risk of death from all causes (including cancer) and say that vitamin D could play an important role in cancer prognosis in a paper ...

Recommended for you

Increased morbidity, mortality in food system industries

date 4 hours ago

(HealthDay)—Occupational morbidity and mortality are elevated across food system industries compared with nonfood system industries, according to a study published online May 12 in the Journal of Occupational an ...

Three issues to consider before selecting EHR

date 5 hours ago

(HealthDay)—Work flow, features and functionality, and technical infrastructure should all be considered in advance of selecting an electronic heath record (EHR) system, according to an article published ...

Research letter: Indoor tanning rates drop among US adults

date 6 hours ago

Indoor tanning rates dropped among adults from 5.5 percent in 2010 to 4.2 percent in 2013, although an estimated 7.8 million women and 1.9 million men still engage in the practice, which has been linked to increased cancer ...

Stunting remains a challenge in South Africa

date 7 hours ago

Stunting remains stubbornly persistent in South Africa, despite economic growth, political and social transitions, and national nutritional programmes, says a Wits-led research team.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.