Modifiable risk factors impact CVD mortality in T2DM

Modifiable risk factors impact CVD mortality in T2DM

(HealthDay)—Modifiable risk factors can be targeted for early and continued intervention to reduce the risk of adverse outcomes in patients with type 2 diabetes mellitus and cardiovascular disease, according to research published online July 2 in Diabetes Care.

Amanda J. Cox, Ph.D., of the Wake Forest School of Medicine in Winston-Salem, N.C., and colleagues analyzed data for a subset of 371 high-risk patients from the Diabetes Heart Study with type 2 diabetes and a coronary artery calcified plaque score greater than 1,000 mg. The researchers compared differences in (CVD) risk factors among 218 living and 153 deceased participants.

The researchers found that duration of type 2 diabetes had been longer (P = 0.02) and use of cholesterol-lowering medications lower (P = 0.004) among deceased participants. After adjustment, vascular calcified plaque scores were found to be associated with higher risk of mortality. Other CVD risk factors found to be associated with 1.1 to 1.5 times higher risk of mortality included higher levels of HbA1c, lipids, and C-reactive protein and reduced kidney function.

"In conclusion, the findings described here suggest that even among individuals with type 2 diabetes and high burden of subclinical CVD, modifiable exist that could be targeted for early and continued intervention to reduce the risk of ," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Serum marker predicts cardiovascular events in diabetes

Apr 25, 2014

(HealthDay)—Elevated levels of polyclonal serum immunoglobulin combined free light chains (cFLCs) may indicate adverse cardiovascular disease (CVD) outcomes in patients with type 2 diabetes, according to ...

Heart health matters to your brain

Jun 04, 2013

June 4, 2013 – People suffering from type 2 diabetes and cardiovascular disease (CVD) are at an increased risk of cognitive decline, according to a new study from Wake Forest Baptist Medical Center.

Recommended for you

Magnesium cuts diabetes risk

1 hour ago

Getting enough magnesium in the diet may reduce the risk of diabetes, especially for those who already show signs of heading that way.

Personalised treatment for stress-related diabetes

Oct 14, 2014

Researchers at Lund University in Sweden are testing a treatment for type 2 diabetes which targets the disease mechanism itself - and not just the symptoms. For the first time, knowledge about the individual patient's genetic ...

Sensors to simplify diabetes management

Oct 13, 2014

For many patients diagnosed with diabetes, treating the disease can mean a burdensome and uncomfortable lifelong routine of monitoring blood sugar levels and injecting the insulin that their bodies don't ...

Androgen receptor signaling tied to insulin resistance

Oct 09, 2014

(HealthDay)—Mouse models show tissue-specific androgen receptor (AR) signaling is involved in regulation of metabolism, which may explain the link between androgen deprivation therapy (ADT) and the development ...

User comments