Neurocognitive deficits seen within days of T1DM diagnosis

Neurocognitive deficits seen within days of T1DM diagnosis

(HealthDay)—Deficits in neurocognitive functioning are evident within days of a type 1 diabetes diagnosis in children and are associated with glycemic control over one year postdiagnosis, according to a study published online June 26 in Diabetes Care.

David D. Schwartz, from the Baylor College of Medicine in Houston, and colleagues conducted neuropsychological testing among 147 children/adolescents (aged 5 to 18 years) during their inpatient hospitalization for new-onset . Comparisons were made to normative data, and they examined associations between neurocognitive performance at diagnosis and one year postdiagnosis.

The researchers found that on most cognitive measures, children with type 1 diabetes performed significantly below expectations (P values < 0.0001). Specifically, large decrements were seen in psychomotor speed, visuomotor integration, and phonemic fluency, compared to the normative mean. All tasks except digit span showed a high incidence of impairment (scores less than second percentile). When controlling for race/ethnicity, sex, and reading ability there was a significant association between dominant-hand psychomotor speed and (hemoglobin A1c ≥9.5 percent [80 mmol/mol]; P = 0.032) one year postdiagnosis. There was a 0.77 percent increase in mean hemoglobin A1c in association with impaired psychomotor speed.

"Psychomotor impairment may be an early marker for a broader neurobehavioral vulnerability that has implications for long-term diabetes management," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Study assesses glucose monitoring trends in tweens

Apr 12, 2012

(HealthDay) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published ...

Chronic hyperglycemia tied to worse surgical outcomes

Mar 16, 2014

(HealthDay)—Chronic hyperglycemia (A1C >8 percent) is associated with poor surgical outcomes, as measured by an increased hospital length of stay (LOS), according to a study published in the March issue ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.