Research could lead to earlier diagnosis, treatment of mental diseases

Dong-Chul Kim and Jean Gao, UT Arlington researchers in the Computer Science and Engineering Department. Credit: UT Arlington

A computer science and engineering associate professor and her doctoral student graduate are using a genetic computer network inference model that eventually could predict whether a person will suffer from bipolar disorder, schizophrenia or another mental illness.

The findings are detailed in the paper "Inference of SNP-Gene Regulatory Networks by Integrating Gene Expressions and Genetic Perturbations," which was published in the June edition of Biomed Research International. The principal investigators were Jean Gao, an associate professor of computer science and engineering, and Dong-Chul Kim, who recently earned his doctorate in computer science and engineering from UT Arlington.

"We looked for the differences between our genetic computer network and the brain patterns of 130 patients from the University of Illinois," Gao said. "This work could lead to earlier diagnosis in the future and treatment for those patients suffering from or schizophrenia. Early diagnosis allows doctors to provide timely treatments that may speed up aid to help affected patients."

The UT Arlington researchers teamed with Jiao Wang of the Beijing Genomics Institute at Wuhan, China; and Chunyu Liu, visiting associate professor at the University of Illinois Department of Psychiatry, on the project.

Gao said the findings also could lead to more individualized drug therapies for those patients in the early stages of mental illnesses.

"Our work will allow doctors to analyze a patient's genetic pattern and apply the appropriate levels of personalized therapy based on patient-specific data," Gao said.

One key to the research is designing or SNP networks, researchers said.

"SNPs are regulators of genes," said Kim, who joins the University of Texas-Pan American this fall as an assistant professor. "Those SNPs visualize how individual genes will act. It gives us more of a complete picture."

The paper is a culmination of four years of work.

Khosrow Behbehani, dean of the College of Engineering, said the research merges the power of computer science and engineering, psychology and genetics.

"This research holds a lot of promise in the area of genetic expression," Behbehani said. "If successful, it opens up the possibility of applying the method to other pathological conditions."

More information: Biomed Research International, www.hindawi.com/journals/bmri/2014/629697/

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JVK
1 / 5 (1) Aug 14, 2014
Re: "The paper is a culmination of four years of work."

The link from SNPs to amino acid substitutions that differentiate all cell types in all individuals of all species of mammals will be difficult to ignore if this work continues. The problem with the logical conclusion that will result from this work is that population geneticists will no longer be able to claim mutations that perturb protein folding are somehow naturally selected to enable the evolution of biodiversity, which is obviously nutrient-dependent and pheromone-controlled by the epigenetic effects of olfactory/pheromonal input on the physiology of nutrient-dependent reproduction.

Indeed, the entirety of the theory of evolution may disappear from further consideration when evolutionary biologists realize nutrient-dependent alterations in SNPs lead to the amino acid substitutions that differentiate cell types, unless mutations -also linked to ecology- perturb the protein folding required for controlled differentiation.
anonymous_9001
5 / 5 (2) Aug 14, 2014
The link from SNPs to amino acid substitutions that differentiate all cell types


Does this apply intraorganismally as well? Are neurons differentiated from osteocytes, for instance, in your body by SNPs?
animah
5 / 5 (1) Aug 15, 2014
pheromone-controlled

From http://www.scienc...1100010X

"In humans, the vomeronasal (pheromone receptor) organ develops in utero but subsequently regresses; all studies agree on its nonfunctional status."

Modern genomics don't lie.

JVK - James V Kohl, you are a spammer and a scammer.

I will keep calling it out and if you continue here I am going to start doing it on the various other forums you post your snake oil crap on like pherotalk et. al.

James V Kohl increasingly discredited:

http://www.ncbi.n...4049134/
JVK
1 / 5 (1) Aug 15, 2014
http://www.nytime...amp;_r=0

"From the microbe's perspective, what we eat is a matter of life and death," Dr. Maley said.

The life and death of all organisms is nutrient-dependent and pheromone-controlled and conserved molecular mechanisms link ecological variation to ecological adaptations in their morphology and behavior.

The idea that someone could discredit the only accurate perspective on the direct link from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man, is as ridiculous as the theory that mutation-initiated natural selection led to the evolution of any species that needs food to survive.

The de novo creation of olfactory receptor genes links species from microbes to man, not mutation-driven evolution.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model
http://www.ncbi.n...3960065/