Ketamine does not adversely affect outcomes

August 4, 2014
Review: ketamine does not adversely affect outcomes

(HealthDay)—For intubated patients, ketamine is unlikely to adversely affect patient outcomes compared with other intravenous sedatives, according to a review published online July 22 in the Annals of Emergency Medicine.

Lindsay Cohen, M.D., from the University of British Columbia in Vancouver, and colleagues conducted a systematic literature review to identify randomized and nonrandomized prospective studies that compared the effect of ketamine with another intravenous sedative in intubated patients. The studies reported at least one outcome of interest (intracranial and cerebral perfusion pressures, neurologic outcomes, length of stay, and mortality).

Ten studies, which included data on 953 patients, met the inclusion criteria. The researchers found that nine of these studies were at high risk of bias in at least one domain, while one study was deemed at low risk of bias in all quality assessment domains. There were small reductions in intracranial pressure within 10 minutes of ketamine administration reported in two studies, while two studies reported an increase. There were no reports of significant differences in cerebral perfusion pressure, neurologic outcomes, intensive care unit length of stay, or mortality.

"According to the available literature, the use of ketamine in does not appear to adversely affect ," conclude the authors.

Explore further: Intravenous fluid used for critically ill patients linked with adverse outcomes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Lifestyle changes cut diabetes risk in high-risk patients

October 16, 2013

(HealthDay)—Comprehensive lifestyle interventions decrease the incidence of type 2 diabetes in high-risk patients, but the benefits are less clear in diagnosed patients, according to a review published in the Oct. 15 issue ...

Higher operator volume linked to better PCI outcomes

June 19, 2014

(HealthDay)—Higher individual operator percutaneous coronary intervention (PCI) volume is associated with better outcomes, according to a review published online June 17 in Circulation: Cardiovascular Quality and Outcomes.

Recommended for you

Monkeys in Asia harbor virus from humans, other species

November 19, 2015

When it comes to spreading viruses, bats are thought to be among the worst. Now a new study of nearly 900 nonhuman primates in Bangladesh and Cambodia shows that macaques harbor more diverse astroviruses, which can cause ...

One-step test for hepatitis C virus infection developed

November 14, 2015

UC Irvine Health researchers have developed a cost-effective one-step test that screens, detects and confirms hepatitis C virus (HCV) infections. Dr. Ke-Qin Hu, director of hepatology services, will present findings at the ...

Computer model reveals deadly route of Ebola outbreak

November 10, 2015

Using a novel statistical model, a research team led by Columbia University's Mailman School of Public Health mapped the spread of the 2014-2015 Ebola outbreak in Sierra Leone, providing the most detailed picture to date ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.