Ketamine does not adversely affect outcomes

Review: ketamine does not adversely affect outcomes

(HealthDay)—For intubated patients, ketamine is unlikely to adversely affect patient outcomes compared with other intravenous sedatives, according to a review published online July 22 in the Annals of Emergency Medicine.

Lindsay Cohen, M.D., from the University of British Columbia in Vancouver, and colleagues conducted a systematic literature review to identify randomized and nonrandomized prospective studies that compared the effect of ketamine with another intravenous sedative in intubated patients. The studies reported at least one outcome of interest (intracranial and cerebral perfusion pressures, neurologic outcomes, length of stay, and mortality).

Ten studies, which included data on 953 patients, met the inclusion criteria. The researchers found that nine of these studies were at high risk of bias in at least one domain, while one study was deemed at low risk of bias in all quality assessment domains. There were small reductions in intracranial pressure within 10 minutes of ketamine administration reported in two studies, while two studies reported an increase. There were no reports of significant differences in cerebral perfusion pressure, neurologic outcomes, intensive care unit length of stay, or mortality.

"According to the available literature, the use of ketamine in does not appear to adversely affect ," conclude the authors.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Higher operator volume linked to better PCI outcomes

Jun 19, 2014

(HealthDay)—Higher individual operator percutaneous coronary intervention (PCI) volume is associated with better outcomes, according to a review published online June 17 in Circulation: Cardiovascular Qu ...

Recommended for you

Restrictions lifted at British bird flu farm

16 minutes ago

Britain on Sunday lifted all restrictions at a duck farm in northern England after last month's outbreak of H5N8 bird flu, the same strain seen in recent cases across Europe.

Recorded Ebola deaths top 7,000

23 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

Dec 20, 2014

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.