Ketamine does not adversely affect outcomes

Review: ketamine does not adversely affect outcomes

(HealthDay)—For intubated patients, ketamine is unlikely to adversely affect patient outcomes compared with other intravenous sedatives, according to a review published online July 22 in the Annals of Emergency Medicine.

Lindsay Cohen, M.D., from the University of British Columbia in Vancouver, and colleagues conducted a systematic literature review to identify randomized and nonrandomized prospective studies that compared the effect of ketamine with another intravenous sedative in intubated patients. The studies reported at least one outcome of interest (intracranial and cerebral perfusion pressures, neurologic outcomes, length of stay, and mortality).

Ten studies, which included data on 953 patients, met the inclusion criteria. The researchers found that nine of these studies were at high risk of bias in at least one domain, while one study was deemed at low risk of bias in all quality assessment domains. There were small reductions in intracranial pressure within 10 minutes of ketamine administration reported in two studies, while two studies reported an increase. There were no reports of significant differences in cerebral perfusion pressure, neurologic outcomes, intensive care unit length of stay, or mortality.

"According to the available literature, the use of ketamine in does not appear to adversely affect ," conclude the authors.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Higher operator volume linked to better PCI outcomes

Jun 19, 2014

(HealthDay)—Higher individual operator percutaneous coronary intervention (PCI) volume is associated with better outcomes, according to a review published online June 17 in Circulation: Cardiovascular Qu ...

Recommended for you

Aid group: No need to isolate staff treating Ebola

15 minutes ago

Doctors Without Borders insisted Friday, after one of its doctors who worked in Guinea came down with Ebola in New York, that quarantines of health workers returning from the hot zone are not necessary when ...

New York on alert over first Ebola case

24 minutes ago

New York went on alert Friday as authorities sought to calm fears among the city's 8.4 million residents after a doctor tested positive for Ebola.

Volunteer guidelines for clinicians in the Ebola epidemic

1 hour ago

Disaster Medicine and Public Health Preparedness Journal has released a novel, informative article that speaks to volunteers within the Ebola epidemic. The article, contributed by a consortium of Boston-based hospitals, is ent ...

US lawmaker: New case raises questions on Ebola

2 hours ago

The new case of Ebola diagnosed in New York City has raised "even more questions about procedures in treating patients and risks to Americans," a Republican committee chairman said Friday.

User comments