Mortality up with CKD in PCI contrast-induced nephropathy

Mortality up with CKD in PCI contrast-induced nephropathy

(HealthDay)—Contrast-induced nephropathy (CIN) is associated with long-term mortality in patients with, but not those without, chronic kidney disease (CKD), according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

Mitsuru Abe, M.D., from the National Hospital Organization Kyoto Medical Center in Japan, and colleagues examined the effect of CIN on long-term mortality after in with or without CKD. Data were included for 4,371 patients who had paired serum creatinine measurements before and after percutaneous coronary intervention.

The researchers found that the incidence of CIN was 5 percent in the study cohort overall, and was 11 percent in patients with CKD and 2 percent in those without CKD (P < 0.0001) A total of 8.6 percent of patients died during a median follow-up of 42.3 months after discharge. CIN correlated with long-term mortality in the entire cohort after adjustment for prespecified confounders (hazard ratio [HR], 2.26; 95 percent confidence interval [CI], 1.62 to 2.29; P < 0.0001). CIN correlated with long-term mortality in patients with CKD (HR, 2.62; 95 percent CI, 1.91 to 3.57; P < 0.0001), but not in patients without CKD (HR, 1.23; 95 percent CI, 0.47 to 2.62; P = 0.6). These results were confirmed in sensitivity analyses.

"In conclusion, CIN was significantly correlated with long-term mortality in patients with CKD but not in those without CKD," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Nonalcoholic fatty liver disease linked to CKD in T1DM

date Apr 09, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published ...

Recommended for you

Catheterization increasing for seniors with STEMI

date 20 hours ago

(HealthDay)—From 1999 to 2009 there was a decrease in the proportion of older adults with ST-segment elevation acute myocardial infarction (STEMI) who did not undergo cardiac catheterization, according ...

Race influences warfarin dose, study says

date May 29, 2015

A new report demonstrates that clinical and genetic factors affecting dose requirements for warfarin vary by race. The study, published online today in Blood, the Journal of the American Society of Hematology (ASH), propose ...

Even moderate BMI reduction could ease A-fib burden

date May 29, 2015

(HealthDay)—Incremental increases in body mass index (BMI) are associated with excess risk of incident, postoperative, and post-ablation atrial fibrillation (AF), according to a review published online ...

Personalized saline may provide solution to heart death

date May 29, 2015

Saline solution is a staple of every hospital. No matter the ailment, doctors have known for more than a century that saline is key to keeping patients hydrated and maintaining their blood pressure levels. ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.