Ludwig Maximilian University of Munich

Mutation disables innate immune system

A Ludwig Maximilian University of Munich team has shown that defects in the JAGN1 gene inhibit the function of a specific type of white blood cells, and account for a rare congenital immune deficiency that ...

Aug 29, 2014
popularity 4.6 / 5 (5) | comments 0

A new regulator of cholesterol levels

A high level of cholesterol in the blood is associated with increased risk for cardiovascular disease. An LMU team has now identified an endogenous regulator of serum cholesterol – which could lead to new ...

Jan 17, 2014
popularity 5 / 5 (4) | comments 0 | with audio podcast

When DNA is out of place

When DNA that turns up in the wrong place in mammalian cells, the innate immune system reacts by secreting interferons. The structure and mode of action of the enzyme that mediates this response have now been elucidated.

Jun 04, 2013
popularity 5 / 5 (3) | comments 0 | with audio podcast

Why tumor cells go on dangerous tours

Tumors become highly malignant when they acquire the ability to colonize other tissues and form metastases. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified a factor that promotes ...

Nov 04, 2013
popularity 4.7 / 5 (3) | comments 0 | with audio podcast

Prostate cancer: Curcumin curbs metastases

Powdered turmeric has been used for centuries to treat osteoarthritis and other illnesses. Its active ingredient, curcumin, inhibits inflammatory reactions. A new study led by a research team at Ludwig-Maximilians-Universität ...

Oct 12, 2012
popularity 5 / 5 (2) | comments 0 | with audio podcast

Immune system foiled by a hairpin

The innate immune system detects invasive pathogens and activates defense mechanisms to eliminate them. Pathogens, however, employ a variety of tricks to block this process. A new study shows how the measles virus thwarts ...

Jan 22, 2013
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Atherosclerosis: Specific microRNAs promote inflammation

(Medical Xpress)—Atherosclerosis, an inflammatory reaction, is at the root of the most common forms of cardiovascular disease. Researchers at Ludwig-Maximilians-Universitaet in Munich have now identified a microRNA that ...

Mar 22, 2013
popularity 5 / 5 (2) | comments 1 | with audio podcast

Cancer therapy: Nanokey opens tumors to attack

There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart ...

Nov 14, 2012
popularity 5 / 5 (1) | comments 0

Why tumor cells leave home

(Medical Xpress)—Malignant cells can escape from primary tumors and colonize new sites in other tissues. In a new study, LMU researchers show how the transcription factor AP4 promotes the development of ...

Jun 11, 2013
popularity 5 / 5 (1) | comments 0

The Janus-like nature of JAM-A

A new study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Christian Weber sheds light on the role of the adhesion molecule JAM-A in the recruitment of immune cells to the inner layer ...

Sep 30, 2013
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Feedback loops and localization errors

Neurobiologists at Ludwig Maximilian University of Munich describe a feedback loop that modulates the processing of auditory signals in the brainstem in a frequency-dependent manner, and can lead to systematic ...

Oct 24, 2013
popularity 5 / 5 (1) | comments 0 | with audio podcast