Scientists from St. Jude Children's Research Hospital have shown that the innate immune sensor, ZBP1, and its associated inflammatory cell death pathway, PANoptosis, are major contributors to the negative effects of interferon ...
May 19, 2022
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Computational scientists at St. Jude Children's Research Hospital have created a tool to find genes and genetic variants that predispose people to rare diseases. Finding genes and genetic variants that contribute to rare ...
May 11, 2022
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Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. However, these drugs are subject to treatment resistance. Scientists at St. Jude Children's Research ...
May 9, 2022
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Scientists at St. Jude Children's Research Hospital have evaluated how vaccination against, and infection with, SARS-CoV-2 affects the immune system. The results confirm that immunity by infection is not better than vaccination ...
Apr 5, 2022
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Scientists from St. Jude Children's Research Hospital have identified variants in two genes that are associated with accelerated aging in childhood cancer survivors. Their research looked at the difference between their ...
Mar 22, 2022
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Scientists at St. Jude Children's Research Hospital and the Cancer Research Center in Spain blocked development of acute lymphoblastic leukemia in mice with a genetic mutation that increases the risk of childhood cancer.
Feb 7, 2022
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Most clinical studies of the immune system use adults. For pediatric cancer patients, that information doesn't tell the full story. Researchers at St. Jude Children's Research Hospital found that the active immune system ...
Feb 7, 2022
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Scientists at St. Jude Children's Research Hospital have developed the first GRP78 targeted chimeric antigen receptor (CAR) T cell. Their GRP78 CAR T cell successfully targeted and destroyed acute myelogenous leukemia (AML) ...
Jan 31, 2022
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Scientists at St. Jude Children's Research Hospital are studying the impact of genetic ancestry on childhood acute lymphoblastic leukemia (ALL), the most common type of pediatric cancer. The team found that ancestry itself ...
Jan 27, 2022
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Prior infection with coronaviruses that cause the common cold impedes the antibody immune response against SARS-CoV-2, the coronavirus responsible for COVID-19. The results from St. Jude Children's Research Hospital appeared ...
Jan 13, 2022
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