Thomas Jefferson University

Medical research

Wiggly microRNA binding implies a more complex genome regulation

MicroRNAs (miRNAs) regulate protein-coding gene abundance levels by interacting with the 3ยด end of various messenger RNAs. Each target site matches the first few nucleotides of the targeting miRNA, the so called "seed" region, ...

Immunology

Can antibiotics cause autoimmunity?

The code for every gene includes a message at the end of it that signals the translation machinery to stop. Some diseases, such as cystic fibrosis and Duchenne muscular dystrophy, can result from mutations that insert this ...

Oncology & Cancer

Cyclin D1 governs microRNA processing in breast cancer

Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA), according to new research publishing November 29 in Nature Communications. ...

Oncology & Cancer

Curry spice component may help slow prostate tumor growth

Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers at Jefferson's ...

Medical research

Single vaccines to protect against both rabies and Ebola

Researchers from Thomas Jefferson University, among other institutions, including the National Institute of Allergy and Infectious Diseases, have developed single vaccines to protest against both rabies and the Ebola virus.

Psychology & Psychiatry

Discussions may improve adherence to diabetes medication

Not taking medications exactly as prescribed is a major barrier to the treatment of diabetes and has been shown to be more common in African American patients than in their white counterparts.

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