Wellcome Trust Sanger Institute

Medical research

Low doses of radiation promote cancer-capable cells

Low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells in healthy tissue, scientists have discovered. Researchers at the Wellcome ...

Oncology & Cancer

CRISPR catches out critical cancer changes

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have ...

Genetics

Mice reveal 38 new genes involved in hearing loss

Multiple new genes involved in hearing loss have been revealed in a large study of mouse mutants by researchers from the Wellcome Sanger Institute and King's College London, and colleagues. The new genes identified reveal ...

Oncology & Cancer

Major mutation pattern in cancer occurs in bursts

Researchers have created a huge resource for investigating the biological mechanisms that cause cancer. The scientists from the Wellcome Sanger Institute and their collaborators identified which patterns of DNA damage—mutational ...

Immunology

Study reveals how immune cells target different tissues

For the first time, researchers have revealed the different molecular identities of important immune cells, called T regulatory cells, using single cell genomics, in both mouse and human peripheral non-lymphoid tissues such ...

Genetics

GARFIELD classifies disease-relevant changes in the genome

Researchers at the Wellcome Sanger Institute and EMBL's European Bioinformatics Institute (EMBL-EBI) have developed a new approach to understand the functional effects of genetic variations associated with a disease, even ...

Immunology

CRISPR study reveals new immune system regulators

Scientists have created the first retroviral CRISPR-Cas9 gene editing library to explore the regulation of mouse T cells, which are key cells in the immune system. Researchers from the Wellcome Sanger Institute and their ...

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