Whitehead Institute for Biomedical Research
High levels of master heat shock protein linked to poor prognosis in breast cancer patients
Whitehead Institute scientists report that patients whose estrogen receptor (ER)-positive breast cancers have high levels of the ancient cellular survival factor heat shock factor 1 (HSF1) experience poor ...
Cancer
Oct 31, 2011 |
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Yeast model connects Alzheimer's disease risk and amyloid beta toxicity
In a development that sheds new light on the pathology of Alzheimer's disease (AD), a team of Whitehead Institute scientists has identified connections between genetic risk factors for the disease and the ...
Medical research
Oct 27, 2011 |
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How major signaling pathways are wired to our genome gives new insight into disease processes
Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each ...
Medical research
Oct 27, 2011 |
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Protein unmasks pathogenic fungi to activate immune response
The first step in defending against a hostile attack is identifying the enemy. It's how a healthy immune system mounts a response to invading pathogens. In the case of certain fungi, however, the attacking cells may be so ...
Medical research
Aug 08, 2011 |
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Key metabolic pathway implicated in intractable form of breast cancer
Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in the serine biosynthesis pathway that is essential in estrogen receptor (ER)-negative breast cancer—a notoriously difficult ...
Cancer
Jul 18, 2011 |
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Precision gene targeting in stem cells corrects disease-causing mutations
Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (adult cells that ...
Genetics
Jul 15, 2011 |
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Signaling pathways point to vulnerability in breast cancer stem cells
Whitehead Institute researchers have identified signals from breast epithelial cells that can induce those cells to transition to and maintain a mesenchymal and stem cell-like cell state that imbues both normal and cancer ...
Medical research
Jun 09, 2011 |
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Leucine deprivation proves deadly to malignant melanoma cells
Whitehead Institute researchers have found that depriving human melanoma cells of the essential amino acid leucine can be lethal to the cells, suggesting a possible strategy for therapeutic intervention.
Cancer
May 16, 2011 |
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Scientists ignore cultural barriers to find the cause of a rare disease
In a research collaboration blind to affairs of politics, ethnicity, and religion, an international team led by Israeli scientists has identified the genetic cause of a neurological disorder afflicting members of a Palestinian ...
Genetics
Apr 11, 2011 |
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Scientists identify a surprising new source of cancer stem cells
Whitehead Institute researchers have discovered that a differentiated cell type found in breast tissue can spontaneously convert to a stem-cell-like state, the first time such behavior has been observed in mammalian cells. ...
Cancer
Apr 11, 2011 |
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