News tagged with amyloidosis

Amyloidosis

In medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it takes on a particular aggregated insoluble form, similar to the beta-pleated sheet. Symptoms vary widely depending upon the site of amyloid deposition, i.e. where in the body these "bad proteins" are found in significant numbers. Amyloidosis may be inherited or acquired.

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It's not just amyloid: White matter hyperintensities and Alzheimer's disease

(Medical Xpress)—New findings by Columbia researchers suggest that along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor for the development of Alzheimer's disease.

Alzheimer's disease & dementia created Feb 19, 2013 | popularity 5 / 5 (1) | comments 0

Amyloid imaging shows promise for detecting cardiac amyloidosis

While amyloid imaging may now be most associated with detecting plaques in the brain, it has the potential to change the way cardiac amyloidosis is diagnosed. According to first-of-its-kind research published in the February ...

Medical research created Feb 04, 2013 | popularity not rated yet | comments 0

A DNA-made trap may explain amyloidosis aggravation

Amyloidosis is a group of clinical syndromes characterized by deposits of amyloid fibrils throughout the body. These fibrils are formed by aggregates of proteins that have not been properly folded. Deposits of amyloid fibrils ...

Medical research created Oct 09, 2012 | popularity 4.5 / 5 (2) | comments 0

Tafamidis: Approval denotes proven added benefit

Tafamidis meglumine (trade name: Vyndaqel) was approved in November 2011 for the treatment of transthyretin amyloidosis in adults. This rare disorder ("orphan disease") is caused by a defective gene and is associated with ...

Medications created Sep 17, 2012 | popularity not rated yet | comments 0

BUSM researchers part of multi-center study on cardiac amyloidosis

Researchers at Boston University School of Medicine (BUSM) have been part of a multicenter observational study called TRACS (Transthyretin Amyloidosis Cardiac Study) to help determine the health significance of a particular ...

Cardiology created Aug 13, 2012 | popularity not rated yet | comments 0

Powerful myeloma treatment regimen shows promise for AL amyloidosis

Two studies published today in Blood, the Journal of the American Society of Hematology (ASH), demonstrate preliminary success of an effective multiple myeloma (MM) regimen in patients with AL amyloidosis, a rare and devast ...

Cancer created Feb 13, 2012 | popularity not rated yet | comments 0

High-dose melphalan and autologous stem cell transplantation increases survival

A team of researchers led by Boston University School of Medicine (BUSM), has found treatment of selected immunoglobulin light chain (AL) amyloidosis patients with high-dose melphalan and autologous stem cell transplantation ...

Cancer created Oct 26, 2011 | popularity 1 / 5 (1) | comments 0 | with audio podcast

Overlooked peptide reveals clues to causes of Alzheimer's disease

Researchers at the RIKEN Brain Science Institute (BSI) and their collaborators have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer's disease (AD). Their surprising findings reveal that ...

Neuroscience created Jul 03, 2011 | popularity 4 / 5 (3) | comments 0 | with audio podcast