Dear Mayo Clinic: The bisphosphonate drugs I take for osteoporosis aren't working in my case. My doctor has suggested a few alternatives. Any thoughts on what might be best?
Oct 17, 2017
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Researchers at the Garvan Institute of Medical Research have revealed that a common osteoporosis treatment boosts immune cells in the lung that form one of the first lines of defense against pathogens.
Jan 6, 2022
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Uli von Andrian is the Mallinckrodt Professor of Immunopathology at Harvard Medical School and Program Leader of Basic Immunology at the Ragon Institute of MGH, MIT, and Harvard.
Apr 10, 2020
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Medicines used to prevent bone loss may help lower the risk of ovarian cancer according to research by The University of Queensland.
Jun 17, 2022
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Osteoporosis is a common disorder among postmenopausal women which results in an increased risk of fractures. While several therapies improve bone strength and reduce the risk of spine and hip fracture, there is no cure for ...
Oct 11, 2017
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Bisphosphonates (a class of drugs that prevent the loss of bone density and used to treat osteoporosis and similar diseases) appear to be safe and beneficial for osteoarthritis patients.
Aug 5, 2020
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Australian researchers have shown why calcium-binding drugs commonly used to treat people with osteoporosis, or with late-stage cancers that have spread to bone, may also benefit patients with tumours outside the skeleton, ...
Nov 5, 2014
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The most commonly used medications for osteoporosis worldwide, bisphosphonates, may also prevent certain kinds of lung, breast and colon cancers, according to two studies led by researchers at the Icahn School of Medicine ...
Dec 1, 2014
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USC researchers and collaborators report a breakthrough to prevent damage to the jaw, a side effect suffered by some people undergoing treatment for cancer or osteoporosis.
Apr 11, 2019
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Patients who take osteoporosis drugs for long periods typically are advised to temporarily discontinue the drugs to prevent rare but serious side effects to the jaw and thighs.
May 4, 2018
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In pharmacology, bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.
Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digestion of bone by osteoclasts.
Osteoclasts also have constant turnover and normally destroy themselves by a process called cell suicide (apoptosis). Bisphosphonates encourage osteoclasts to undergo apoptosis.
The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta and other conditions that feature bone fragility.
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