News tagged with brca1
Study finds new member of the breast-cancer gene network
The infamous BRCA genes do not act alone in causing cancer; there is a molecular syndicate at work preventing the way cells normally repair breaks in DNA that is at the root of breast cancer. But finding all ...
Cancer
Feb 22, 2012 |
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Hundreds more breast cancer patients should be tested for BRCA1 gene
(Medical Xpress) -- Leading breast cancer experts are calling for women under 50 who are diagnosed with triple-negative (TN) breast cancer to be offered testing for faults in the BRCA1 gene, according to a report published ...
Cancer
Feb 15, 2012 |
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Joint patent for using the BRCA1 gene as a therapy for cardiovascular disease
St. Michael's Hospital and King Saud University have received their first joint U.S. patent to use the BRCA1 gene as a therapy for cardiovascular disease.
Genetics
Feb 10, 2012 |
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Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed
Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.
Cancer
Jan 27, 2012 |
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Breast cancer and heart disease may have common roots
Women who are at risk for breast cancer may also be at greater risk for heart disease, new research has found.
Genetics
Dec 20, 2011 |
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Risk for developing new cancer in other breast increased for survivors with BRCA mutation
Breast cancer survivors who carry the BRCA1 or BRCA2 genetic mutation are at high risk for developing contralateral breast cancer — a new primary tumor in the other breast — and certain women within this group of ...
Cancer
Dec 08, 2011 |
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Ovarian cancer patients survive longer with BRCA2 mutated in tumors
Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers at The University of Texas MD Anderson Cancer Center and the Institute ...
Cancer
Oct 11, 2011 |
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BRCA2 genetic mutation associated with improved survival, chemotherapy response in ovarian cancer
Among women with a certain type of high-grade ovarian cancer, having BRCA2 genetic mutations, but not BRCA1, was associated with improved overall survival and improved response to chemotherapy, compared to women with BRCA ...
Cancer
Oct 11, 2011 |
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BRCA1 gene mutation associated with neoadjuvant chemotherapy
Nearly half of breast cancer patients carrying the BRCA1 gene mutation experience a complete pathological response (pCR) – the disappearance of all evidence of disease from the breast tissue and lymph nodes – regardless ...
Cancer
Sep 06, 2011 |
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Key function of mutation in hereditary breast and ovarian cancer gene discovered
It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers ...
Genetics
Sep 01, 2011 |
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Olaparib shows promise in treating ovarian cancer, even without BRCA mutations
The PARP inhibitor, olaparib, that has shown promise in women with an inherited mutation in their BRCA1 or BRCA2 gene (accounting for about 5-10% of breast and ovarian cancer cases), has, for the first time, been shown to ...
Cancer
Aug 21, 2011 |
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Faulty gene connected to ovarian cancer risk
In a new study published in Nature Genetics researchers say that women who possess a fault in a gene named RAD51D have a greater risk of developing ovarian cancer than women who do not have this fault and tests are expect ...
Cancer
Aug 09, 2011 |
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Progressive telomere shortening characterizes familial breast cancer patients
Telomeres, the complex structures that protect the end of chromosomes, of peripheral blood cells are significantly shorter in patients with familial breast cancer than in the general population. Results of the study carried ...
Cancer
Jul 29, 2011 |
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Mismatch between cancer genetics counseling and testing guidelines and physician practices
A new analysis has found that many doctors report that they do not appropriately offer breast and ovarian cancer counseling and testing services to their female patients. Published early online in CANCER, a peer-reviewed journa ...
Cancer
Jul 25, 2011 |
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Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal
Women with the BRCA1 or BRCA2 gene mutations, which are linked to a very high risk of breast and ovarian cancer, can safely take hormone-replacement therapy (HRT) to mitigate menopausal symptoms after surgical removal of ...
Cancer
Jun 01, 2011 |
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BRCA1
BRCA1 ( /ˈbrækə/; breast cancer 1, early onset) is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990. The gene was later cloned in 1994 by scientists at Myriad Genetics.
BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, or destroy cells if DNA cannot be repaired. If BRCA1 itself is damaged, damaged DNA is not repaired properly and this increases risks for cancers.
The protein encoded by the BRCA1 gene combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, DNA repair of double-stranded breaks ubiquitination, transcriptional regulation as well as other functions.
For more information about BRCA1, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
