News tagged with brca1
PARP inhibitor shows activity in pancreatic, prostate cancers among patients carrying BRCA mutations
In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced ...
Cancer May 15, 2013 | not rated yet | 0
Actress Angelina Jolie has today written an op-ed in the New York Times explaining that she has opted to have a double mastectomy because she carries the hereditary BRCA1 gene, which she says increases her risk o ...
Cancer May 15, 2013 | 5 / 5 (1) | 2
Researchers of the hereditary cancer research group at the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO) conducted a functional and structural study of seven missense variants ...
Cancer Apr 18, 2013 | not rated yet | 0
Patients with BRCA1 mutations, but not BRCA2 mutations, had poorer prognosis compared with noncarriers
Patients with breast cancer who had a BRCA1 mutation had significantly worse overall and recurrence-free survival rates compared with patients without BRCA mutations, but no evidence for a difference in survival was found ...
Cancer Apr 09, 2013 | 5 / 5 (1) | 0
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences associated with breast cancer—the most common cancer among women, with an average risk of developing the disease of 10 percent—and ovarian cancer, ...
Cancer Mar 27, 2013 | 5 / 5 (1) | 0
Chemotherapy given straight into the abdomen of certain ovarian cancer patients could allow them to live an extra three years on average, according to new research published in the British Journal of Cancer.
Cancer Mar 06, 2013 | not rated yet | 0
(HealthDay)—Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study.
Cancer Feb 20, 2013 | not rated yet | 0
A 23andMe study of consumers' reactions to genetic testing found that even when the tests revealed high-risk mutations in individuals, those individuals had few negative reactions to the news. Instead of inducing serious ...
Cancer Feb 12, 2013 | not rated yet | 0
(Medical Xpress)—A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers ...
Cancer Feb 06, 2013 | 5 / 5 (1) | 0 |
Women with harmful mutations in the BRCA gene, which put them at higher risk of developing breast and ovarian cancer, tend to undergo menopause significantly sooner than other women, allowing them an even ...
Cancer Jan 29, 2013 | not rated yet | 0 |
A new multiple gene expression profile test was able to predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women carrying the mutations, according to data published in Cancer Prevention Research, a jour ...
Cancer Jan 22, 2013 | not rated yet | 0 |
Our DNA, which stores our genetic information, is constantly exposed to damage. If not properly repaired, DNA damage can lead to cell death. This, in turn, can lead to tissue exhaustion and ageing, or induce mutations resulting ...
Cancer Jan 03, 2013 | 5 / 5 (1) | 0
(Medical Xpress)—A team of researchers led by the Institute of Cancer Research, London, have found that rare mutations in a gene called PPM1D are linked to an increased risk of breast and ovarian cancer. The mutations are ...
Cancer Dec 17, 2012 | 5 / 5 (1) | 0 |
A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth.
Cancer Dec 17, 2012 | not rated yet | 0 |
About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, new research from the University of Michigan Comprehensive ...
Cancer Nov 27, 2012 | not rated yet | 0
BRCA1 ( /ˈbrækə/; breast cancer 1, early onset) is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990. The gene was later cloned in 1994 by scientists at Myriad Genetics.
BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, or destroy cells if DNA cannot be repaired. If BRCA1 itself is damaged, damaged DNA is not repaired properly and this increases risks for cancers.
The protein encoded by the BRCA1 gene combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, DNA repair of double-stranded breaks ubiquitination, transcriptional regulation as well as other functions.
For more information about BRCA1, read the full article at
This text uses material from Wikipedia and is available under the GNU Free Documentation License.