News tagged with brca1
PARP inhibitor shows activity in pancreatic, prostate cancers among patients carrying BRCA mutations
In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced ...
Cancer
May 15, 2013 |
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What is BRCA1?
Actress Angelina Jolie has today written an op-ed in the New York Times explaining that she has opted to have a double mastectomy because she carries the hereditary BRCA1 gene, which she says increases her risk o ...
Cancer
May 15, 2013 |
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Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed
Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.
Cancer
Jan 27, 2012 |
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Scientists identify molecular link between metabolism and breast cancer
(Medical Xpress)—A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers ...
Cancer
Feb 06, 2013 |
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Diagnostic chest radiation before 30 may increase breast cancer risk
Women carrying a mutation in the BRCA1- or BRCA2- genes (which control the suppression of breast and ovarian cancer) who have undergone diagnostic radiation to the chest before the age of 30 are more likely to develop breast ...
Cancer
Sep 06, 2012 |
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Scientists discover gene linked to breast and ovarian cancer
(Medical Xpress)—A team of researchers led by the Institute of Cancer Research, London, have found that rare mutations in a gene called PPM1D are linked to an increased risk of breast and ovarian cancer. The mutations are ...
Cancer
Dec 17, 2012 |
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Faulty gene connected to ovarian cancer risk
In a new study published in Nature Genetics researchers say that women who possess a fault in a gene named RAD51D have a greater risk of developing ovarian cancer than women who do not have this fault and tests are expect ...
Cancer
Aug 09, 2011 |
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Study uncovers mechanism used by BRCA1 to suppress tumors
A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth.
Cancer
Dec 17, 2012 |
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After chest radiation, girls at greater risk for early breast cancer: study
(HealthDay) -- Girls who receive radiation to the chest to treat childhood cancer, even those getting lower doses, have a high risk of developing breast cancer at a young age, according to a new study.
Cancer
Jun 04, 2012 |
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Hundreds more breast cancer patients should be tested for BRCA1 gene
(Medical Xpress) -- Leading breast cancer experts are calling for women under 50 who are diagnosed with triple-negative (TN) breast cancer to be offered testing for faults in the BRCA1 gene, according to a report published ...
Cancer
Feb 15, 2012 |
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Gene mutation study results could lead to less expensive, more accessible breast and ovarian cancer screening
(Medical Xpress)—Researchers conducting a study of gene mutations that increase a woman's likelihood of breast and ovarian cancers have made a discovery that could open doors to less expensive and more ...
Cancer
Sep 17, 2012 |
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Early menopause may occur in women with BRCA gene, study finds
Women with harmful mutations in the BRCA gene, which put them at higher risk of developing breast and ovarian cancer, tend to undergo menopause significantly sooner than other women, allowing them an even ...
Cancer
Jan 29, 2013 |
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Study finds new member of the breast-cancer gene network
The infamous BRCA genes do not act alone in causing cancer; there is a molecular syndicate at work preventing the way cells normally repair breaks in DNA that is at the root of breast cancer. But finding all ...
Cancer
Feb 22, 2012 |
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New test predicted presence of harmful BRCA mutations
A new multiple gene expression profile test was able to predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women carrying the mutations, according to data published in Cancer Prevention Research, a jour ...
Cancer
Jan 22, 2013 |
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Gene mutation's benefit for ovarian cancer patients may not last: study
(HealthDay)—Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study.
Cancer
Feb 20, 2013 |
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BRCA1
BRCA1 ( /ˈbrækə/; breast cancer 1, early onset) is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990. The gene was later cloned in 1994 by scientists at Myriad Genetics.
BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, or destroy cells if DNA cannot be repaired. If BRCA1 itself is damaged, damaged DNA is not repaired properly and this increases risks for cancers.
The protein encoded by the BRCA1 gene combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, DNA repair of double-stranded breaks ubiquitination, transcriptional regulation as well as other functions.
For more information about BRCA1, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
