Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Publishing in the September ...
Sep 24, 2019
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109
Researchers at The Wistar Institute have described a novel role of nicotinamide adenine dinucleotide (NAD+) metabolism in the ability of senescent cells to release tumor-promoting molecules. This study, published online in ...
Feb 19, 2019
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105
A type of cellular stress known to be involved in cancer and aging has now been implicated, for the first time, in Alzheimer's disease. UT Health San Antonio faculty researchers reported the discovery Monday [August 20, 2018] ...
Aug 22, 2018
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586
What's the secret to aging well? University of Minnesota Medical School researchers have answered it- on a cellular level.
Aug 15, 2018
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1371
A new study from University of Minnesota Medical School researchers has demonstrated that psychosocial stress can shorten the lifespan in mice. For years, stress and socio-economic status has been connected to morbidity and ...
May 29, 2018
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146
With their large buck teeth and wrinkled, hairless bodies, naked mole rats won't be winning any awards for cutest rodent. But their long life span—they can live up to 30 years, the longest of any rodent—and remarkable ...
Feb 6, 2018
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325
As cells age and stop dividing, their fat content changes, along with the way they produce and break down fat and other molecules classified as lipids, according to a new University at Buffalo study.
Jan 19, 2017
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701
New research shows that a cellular program that causes aging can also bring unexpected benefits in the function of pancreatic beta cells and the production of insulin in mice and humans. The findings are reported in the journal ...
Mar 7, 2016
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10
Buck Institute faculty Judith Campisi, PhD, says age researchers need to stop thinking of cellular senescence, now accepted as an important driver of aging, as a single phenotype that stems from genotoxic stress. Research ...
Dec 10, 2015
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145
Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies. ...
Jul 6, 2015
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