Medical research
Cellular senescence: When growth stimulation meets cell cycle arrest
A new review paper titled "Cellular senescence: when growth stimulation meets cell cycle arrest" has been published in Aging.
Mar 2, 2023
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News tagged with cellular signaling pathway
Medical research
Clearance of p16Ink4a+ cells: Limited effects on β-cell mass and proliferation in mice
A new research paper titled "Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity" has been published in Aging.
Jan 31, 2023
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Medical research
Downregulation of senescence-associated secretory phenotype by knockdown of SFRP4 contributes to skin aging prevention
There is growing evidence that the appearance and texture of the skin that is altered during the aging process are considerably enhanced by the accumulation of senescent dermal fibroblasts. These senescent cells magnify aging ...
Oct 31, 2022
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Oncology & Cancer
Hallmarks of cancer and hallmarks of aging reviewed
Dr. Mikhail Blagosklonny has published his new review paper titled "Hallmarks of cancer and hallmarks of aging" in Aging Volume 14, Issue 9.
May 18, 2022
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Diseases, Conditions, Syndromes
Researchers identify specific genes and cell pathways as key players in rare female lung disease
Deleting the TSC2 gene in specific lung cells of mice led to the activation of the mTORC1 signaling pathway and pulmonary disease characteristics consistent with human LAM disease, particularly in female breeder mice. These ...
Nov 9, 2020
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Medical research
Scientists identify a genetic basis for healthy sleep
From organisms as simple as worms to those as complex as humans, sleep is a fundamental necessity. But although an estimated 50 to 70 million people in the United States suffer from a chronic sleep disorder, the genetic mechanisms ...
Nov 14, 2019
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201
Ophthalmology
Gene changes driving myopia reveal new focus for drug development
Myopia (nearsightedness) and hyperopia (farsightedness) develop through different molecular pathways, according to a new study publishing October 9 in the open-access journal PLOS Biology by Andrei Tkatchenko of Columbia ...
Oct 9, 2018
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Diseases, Conditions, Syndromes
Study describes enzyme's key role in immune response to Chagas disease parasite
In an article published recently in the journal Nature Communications, researchers affiliated with the University of São Paulo (USP) in Brazil describe the central role played by an enzyme called phosphatidylinositol 3-kinase ...
Jul 16, 2018
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Oncology & Cancer
Potential new treatment identified for drug-resistant skin cancer
Stanford researchers have learned how basal cell carcinoma evades drug treatment without mutating. The researchers found possible drug targets that may allow for more personalized treatment of this common skin cancer.
Feb 6, 2018
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Diseases, Conditions, Syndromes
Metabolic pathway involved in immune response to Zika also participates in neurogenesis
Researchers at the University of Campinas (UNICAMP) in São Paulo State, Brazil, have identified molecules that serve as markers of Zika in blood serum taken from patients with this viral infection.
Jan 10, 2018
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