News tagged with chemotherapy
Study IDs key protein for cell death, offers way to kill cancer cells by forcing them into programmed-death pathway
When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs have ...
Genetics May 14, 2013 | 5 / 5 (9) | 0 |
Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn't kill the cancer cells the way it's supposed to. New research from Western University ...
Cancer 22 hours ago | 5 / 5 (3) | 0
By tracking changes in patients' blood, Cambridge scientists have created a new way of looking at how tumours evolve in real-time and develop drug resistance. The research was published in the print edition ...
Cancer May 03, 2013 | 5 / 5 (2) | 0 |
(Medical Xpress)—Weight-bearing exercise, often prescribed to combat bone loss, might have anti-cancer effects. Cornell biomedical researchers report that mechanical stimulation of cancerous bone, in making ...
Cancer May 07, 2013 | 5 / 5 (2) | 0 |
Through the serendipity of science, researchers at the University of Pittsburgh have discovered a potential treatment for deadly, drug-resistant bacterial infections that uses the same approach that HIV uses to infect cells. ...
Medical research May 07, 2013 | 5 / 5 (1) | 0 |
Scientists from Flinders University are trying to develop a new treatment for a highly aggressive, asbestos-related lung cancer that is set to become more prevalent in the future.
Cancer May 16, 2013 | 5 / 5 (1) | 0
Sleeping sickness kills tens of thousands of people in Africa each year. Current chemotherapies are subject to various limitations, including resistance. Rhodesain, an enzyme of the parasites that cause this ...
Cancer May 17, 2013 | 4 / 5 (1) | 1 |
Cancer chemotherapy can cause peripheral neuropathy—nerve damage often resulting in pain and muscle weakness in the arms and legs. Now, researchers at Albert Einstein College of Medicine of Yeshiva University have discovered ...
Medical research May 05, 2013 | 3 / 5 (1) | 0 |
Chemotherapy, in its most general sense, refers to treatment of disease by chemicals that kill cells, both good and bad, but specifically those of micro-organisms or cancerous tumours. In popular usage, it refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a cytotoxic standardized treatment regimen. In its non-oncological use, the term may also refer to antibiotics (antibacterial chemotherapy). In that sense, the first modern chemotherapeutic agent was Paul Ehrlich's arsphenamine, an arsenic compound discovered in 1909 and used to treat syphilis. This was later followed by sulfonamides discovered by Domagk and penicillin discovered by Alexander Fleming.
Most commonly, chemotherapy acts by killing cells that divide rapidly, one of the main properties of cancer cells. This means that it also harms cells that divide rapidly under normal circumstances: cells in the bone marrow, digestive tract and hair follicles; this results in the most common side effects of chemotherapy—myelosuppression (decreased production of blood cells), mucositis (inflammation of the lining of the digestive tract) and alopecia (hair loss).
Other uses of cytostatic chemotherapy agents (including the ones mentioned below) are the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and the suppression of transplant rejections (see immunosuppression and DMARDs). Newer anticancer drugs act directly against abnormal proteins in cancer cells; this is termed targeted therapy.
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