Diseases, Conditions, Syndromes

Mystery of Yemen cholera epidemic solved

The most likely source of the cholera epidemic in Yemen has been discovered by scientists. Through the use of genomic sequencing, scientists at the Wellcome Sanger Institute and Institut Pasteur estimate the strain of cholera ...

Diseases, Conditions, Syndromes

Nigeria faces one of its worst cholera outbreaks in years

Nigeria is seeing one of its worst cholera outbreaks in years, with more than 2,300 people dying from suspected cases as Africa's most populous country struggles to deal with multiple disease outbreaks.

Diseases, Conditions, Syndromes

Weather forecast could predict cholera outbreaks: study

With recent deadly cholera outbreaks in Haiti and Cameroon providing the latest indication of a menacingly resurgent disease, scientists have discovered rain and temperature fluctuations in at-risk areas could predict epidemics ...

Health

After PCs, Bill Gates sets out to reinvent WCs

The man who reinvented computers and made PCs a household item in most wealthy nations, Microsoft tycoon turned philanthropist Bill Gates, is now focusing his attention on recasting the WC.

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Cholera

Cholera, sometimes known as Asiatic or epidemic cholera, is an infectious gastroenteritis caused by enterotoxin-producing strains of the bacterium Vibrio cholerae. Transmission to humans occurs through eating food or drinking water contaminated with Vibrio cholerae from other cholera patients. The major reservoir for cholera was long assumed to be humans themselves, but considerable evidence exists that aquatic environments can serve as reservoirs of the bacteria.

Vibrio cholerae is a Gram-negative bacterium that produces cholera toxin, an enterotoxin, whose action on the mucosal epithelium lining of the small intestine is responsible for the disease's most salient characteristic, exhaustive diarrhea. In its most severe forms, cholera is one of the most rapidly fatal illnesses known, and a healthy person's blood pressure may drop to hypotensive levels within an hour of the onset of symptoms; infected patients may die within three hours if medical treatment is not provided. In a common scenario, the disease progresses from the first liquid stool to shock in 4 to 12 hours, with death following in 18 hours to several days, unless oral rehydration therapy is provided.

The majority of reported cholera cases worldwide occur in Africa. It is estimated that most cases of cholera are unreported due to poor surveillance systems, particularly in Africa. Fatality rates are 5% of total cases in Africa, and less than 1% elsewhere. For a map of recent international outbreaks, see:[3]

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