News tagged with dna alteration
Scientists pair blood test and gene sequencing to detect cancer
Scientists at the Johns Hopkins Kimmel Cancer Center have combined the ability to detect cancer DNA in the blood with genome sequencing technology in a test that could be used to screen for cancers, monitor cancer patients ...
Cancer
Nov 28, 2012 |
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ENCODE project: Researchers catalogue functional elements of the genome
Most of the DNA alterations that are tied to disease do not alter protein-coding genes, but rather the "switches" that control them. Characterizing these switches is one of many goals of the ENCODE project ...
Genetics
Sep 05, 2012 |
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Scientists find that chromosomal abnormalities are associated with aging and cancer
(Medical Xpress) -- Two new studies have found that large structural abnormalities in chromosomes, some of which have been associated with increased risk of cancer, can be detected in a small fraction of people without a ...
Genetics
May 08, 2012 |
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Hopkins team discovers how DNA changes
Using human kidney cells and brain tissue from adult mice, Johns Hopkins scientists have uncovered the sequence of steps that makes normally stable DNA undergo the crucial chemical changes implicated in cancers, psychiatric ...
Medical research
Apr 14, 2011 |
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Scientists find mutation driving pediatric brain tumors
A type of low-grade but sometimes lethal brain tumor in children has been found in many cases to contain an unusual mutation that may help to classify, diagnose and guide the treatment of the tumors, report scientists at ...
Genetics
Apr 30, 2013 |
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Discovery of new class of damage-prone DNA regions could lead to better cancer treatments
Cancer is thought to arise from DNA damage at fragile sites in the genome. A study published by Cell Press on January 24th in the journal Cell reveals a new class of fragile sites that contributes to DNA ...
Cancer
Jan 24, 2013 |
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A mother's nutrition—before pregnancy—may alter the function of her children's genes
Everyone knows that what mom eats when pregnant makes a huge difference in the health of her child. Now, new research in mice suggests that what she ate before pregnancy might be important too. According to a new research ...
Genetics
Sep 20, 2012 |
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Existing drugs offer new treatment options for high-risk childhood leukemia subtype
Scientists have identified new genetic alterations underlying a high-risk subtype of the most common childhood cancer that could be effectively targeted with existing leukemia therapies.
Cancer
Aug 13, 2012 |
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New melanoma driver genes found in largest DNA sequencing study to date
(Medical Xpress) -- Yale Cancer Center geneticists, biochemists, and structural biologists have painted the most comprehensive picture yet of the molecular landscape of melanoma, a highly aggressive and often ...
Genetics
Jul 29, 2012 |
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New research shows childhood adversity causes changes in genetics
In a look at how major stressors during childhood can change a person's biological risk for psychiatric disorders, researchers at Butler Hospital have discovered a genetic alteration at the root of the association. The research, ...
Genetics
Feb 27, 2012 |
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Defects in the packaging of DNA in malignant brain tumors
Glioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently ...
Cancer
Jan 30, 2012 |
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Research gives new hope to those with rare vascular cancer
A specific genetic alteration has been discovered as a defining feature of epithelioid hemangioendothelioma (EHE), a rare but devastating vascular cancer. These findings have also been used to develop a new diagnostic test ...
Cancer
Aug 31, 2011 |
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Two genes linked to why telomeres stretch in cancer cells
Scientists at Johns Hopkins have provided more clues to one of the least understood phenomena in some cancers: why the "ends caps" of cellular DNA, called telomeres, lengthen instead of shorten.
Cancer
Jun 30, 2011 |
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Wip1 could be new target for cancer treatment
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new ...
Cancer
May 06, 2013 |
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Unique study reveals genetic 'spelling mistakes' that increase the risk of common cancers
More than 80 genetic 'spelling mistakes' that can increase the risk of breast, prostate and ovarian cancer have been found in a large, international research study within the framework of the EU Network COGS. For the first ...
Cancer
Mar 27, 2013 |
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