News tagged with dopamine

Related topics: brain , parkinson s disease , brain cells , attention deficit hyperactivity disorder , biological psychiatry

GDNF not needed by the midbrain dopamine system

A key factor in the motor symptoms associated with Parkinson's disease is the gradual destruction of dopamine neurons. The glial cell-derived neurotrophic factor, or GDNF, has been proven to protect dopamine neurons in test ...

Mar 04, 2015
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Dopamine helps with math rules as well as mood

The chemical messenger dopamine – otherwise known as the happiness hormone – is important not only for motivation and motor skills. It seems it can also help neurons with difficult cognitive tasks. Torben ...

Dec 05, 2014
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Dopamine

Dopamine is a neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4, and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary.

Dopamine can be supplied as a medication that acts on the sympathetic nervous system, producing effects such as increased heart rate and blood pressure. However, because dopamine cannot cross the blood-brain barrier, dopamine given as a drug does not directly affect the central nervous system. To increase the amount of dopamine in the brains of patients with diseases such as Parkinson's disease and dopa-responsive dystonia, L-DOPA (levodopa), which is the precursor of dopamine, can be given because it can cross the blood-brain barrier.

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