Oncology & Cancer

Neural stem cell therapy may improve metastatic cancer survival

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according ...

Oncology & Cancer

DNA nanotubes deliver therapeutics to glioblastoma tumors

Glioblastoma is widely considered the most aggressive brain cancer. Even with treatment, patient survival rates are low, with most living an average of 15–18 months after diagnosis. Because of the highly diverse characteristics ...

Neuroscience

A digital reconstruction of the brain's power source

The EPFL Blue Brain Project has created the first digital reconstruction of the Neuro-Glia-Vascular Architecture providing a new framework to study brain function in health and disease. The study, published in Cerebral Cortex, ...

Medical research

Zika virus-specific therapy protects the fetal mouse brain

A gene-silencing therapy protected against Zika virus transmission from pregnant mice to the mouse fetuses, finds a study published November 10th in the journal Molecular Therapy. The treatment, which harnesses nanoparticles ...

Biomedical technology

Mimicking nature to provide long-lasting local anesthesia

Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and muscles, and are an ...

Medical research

Researchers develop 'dimmer switch' to help control gene therapy

In a major advancement in the field of gene therapy for rare and devastating diseases, researchers at Children's Hospital of Philadelphia (CHOP) have developed a "dimmer switch" system that can control levels of proteins ...

Radiology & Imaging

Enhancing drug delivery with ultrasound

It can be difficult to get drugs to disease sites along the gastrointestinal tract, which spans the mouth, esophagus, stomach, small and large intestine, and anus. Invasive treatments can take hours as patients wait for adequate ...

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