World-first tissue study could re-shape future of advanced prostate cancer treatment
The first-ever comprehensive study of prostate cancer tissue has revealed a completely new gene network driving the disease in patients who have stopped responding to standard hormone treatment, according ...
Cancer
Dec 21, 2012 |
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Research reveals new drug target urgently needed for tuberculosis therapy
One third of the world is infected with the bacterium that causes tuberculosis (TB), a disease that is increasingly difficult to treat because of wide spread resistance to available drugs. Researchers from the Institute of ...
Diseases, Conditions, Syndromes
Dec 20, 2012 |
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Study finds new targets for drugs to defeat aggressive brain tumor
University of Pittsburgh Cancer Institute (UPCI) researchers have identified over 125 genetic components in a chemotherapy-resistant, brain tumor-derived cell line, which could offer new hope for drug treatment to destroy ...
Cancer
Dec 14, 2012 |
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Cancer stem cells isolated from kidney tumors
Scientists have isolated cancer stem cells that lead to the growth of Wilms' tumours, a type of cancer typically found in the kidneys of young children. The researchers have used these cancer stem cells to test a new therapeutic ...
Cancer
Dec 13, 2012 |
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Study paves way to design drugs aimed at multiple protein targets at once
An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively ...
Medical research
Dec 12, 2012 |
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TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
Genomic sequencing has revealed therapeutic drug targets for difficult-to-treat, metastatic triple-negative breast cancer (TNBC), according to an unprecedented study by the Translational Genomic Research Institute (TGen) ...
Cancer
Dec 06, 2012 |
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Genome-scale study identifies hundreds of potential drug targets for Huntington's disease
Scientists searching for ways to develop treatments for Huntington's disease (HD) just got a roadmap that could dramatically speed their discovery process. Researchers at the Buck Institute have used RNA interference (RNAi) ...
Genetics
Nov 29, 2012 |
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Doubling down against diabetes: Turbo-charged gut hormones
A collaboration between scientists in Munich, Germany and Bloomington, USA may have overcome one of the major challenges drug makers have struggled with for years: Delivering powerful nuclear hormones to specific tissues, ...
Medical research
Nov 13, 2012 |
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Molecular 'portraits' of tumours match patients with trials in everyday clinical practice
Researchers in France are taking advantage of the progress in genetic and molecular profiling to analyse the make-up of individual cancer patients' tumours and, using this information, assign them to particular treatments ...
Cancer
Nov 08, 2012 |
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First trial in humans of 'minicells': A completely new way of delivering anti-cancer drugs
A completely new way of delivering anti-cancer drugs to tumours, using 'minicells' derived from bacteria, has been tested for the first time in humans and found to be safe, well-tolerated and even induced stable disease in ...
Cancer
Nov 08, 2012 |
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Researchers develop non-invasive technique for predicting patients' response to chemotherapy
Researchers have developed a non-invasive way of predicting how much of a cancer-killing drug is absorbed by a tumour. The preliminary study, which will be reported at the 24th EORTC-NCI-AACR Symposium on Molecular Targets ...
Cancer
Nov 07, 2012 |
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Patients with aberrations in two genes respond better to drugs blocking a well-known cancer pathway
Cancer patients with mutations or variations in two genes -– PIK3CA and PTEN -– who have failed to respond to several, standard treatments, respond significantly better to anti-cancer drugs that inhibit these genes' pathways ...
Cancer
Nov 07, 2012 |
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New drug target found for cystic fibrosis lung disease
Vancouver researchers have discovered the cellular pathway that causes lung-damaging inflammation in cystic fibrosis (CF), and that reducing the pathway's activity also decreases inflammation. The finding offers a potential ...
Inflammatory disorders
Nov 07, 2012 |
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Discovery advances fight against phleboviruses
(Medical Xpress)—Researchers in the Life Sciences Institute at the University of Michigan have discovered how a particular type of virus hides and protects its genetic information from the immune system, ...
Medical research
Nov 07, 2012 |
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Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
Scientists in the United States have tested all possible pairings of the 100 cancer drugs approved for use in patients in order to discover whether there are any combinations not tried previously that are effective in certain ...
Cancer
Nov 06, 2012 |
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