Hundreds of alterations and potential drug targets to starve cancer tumors identified
A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis, conducted by researchers at Columbia University Medical Center, ...
Cancer
Apr 21, 2013 |
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Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control
Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful.
Medical research
Apr 07, 2013 |
4.9 / 5 (7) |
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Compound stimulates tumor-fighting protein in cancer therapy
A compound that stimulates the production of a tumor-fighting protein may improve the usefulness of the protein in cancer therapy, according to a team of researchers.
Cancer
Feb 06, 2013 |
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Study: Most-used diabetes drug works in different way than previously thought
A team, led by senior author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University ...
Diabetes
Jan 06, 2013 |
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Study paves way to design drugs aimed at multiple protein targets at once
An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively ...
Medical research
Dec 12, 2012 |
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Discovery advances fight against phleboviruses
(Medical Xpress)—Researchers in the Life Sciences Institute at the University of Michigan have discovered how a particular type of virus hides and protects its genetic information from the immune system, ...
Medical research
Nov 07, 2012 |
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Study identifies adhesion molecules key to cancer's spread through the body
Although tumor metastasis causes about 90 percent of cancer deaths, the exact mechanism that allows cancer cells to spread from one part of the body to another is not well understood. One key question is ...
Cancer
Oct 09, 2012 |
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New nanoparticles that shut off cancer genes shrink tumors in mice
By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly ...
Cancer
Aug 15, 2012 |
5 / 5 (7) |
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Scientists identify potential target for treating anhedonia - major symptom of depression
Stanford University School of Medicine scientists have laid bare a novel molecular mechanism responsible for the most important symptom of major depression: anhedonia, the loss of the ability to experience pleasure. While ...
Medical research
Jul 11, 2012 |
4.3 / 5 (6) |
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Hulk smash? Maybe not anymore: scientists block excess aggression in mice
Pathological rage can be blocked in mice, researchers have found, suggesting potential new treatments for severe aggression, a widespread trait characterized by sudden violence, explosive outbursts and hostile overreactions ...
Neuroscience
Jun 19, 2012 |
3.8 / 5 (6) |
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Map of substrate-kinase interactions may lead to more effective cancer drugs
(Medical Xpress) -- Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help drugmakers close ...
Cancer
Mar 27, 2012 |
5 / 5 (1) |
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Tranylcypromine antidepressant shows promise as cancer treatment
A retinoid called all-trans retinoic acid (ATRA), which is a vitamin A-derivative, is already used successfully to treat a rare sub-type of acute myeloid leukemia (AML), however this drug has not been effective for the more ...
Cancer
Mar 11, 2012 |
5 / 5 (1) |
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Scientists uncover mechanism for melanoma drug resistance
Cancer is tough to kill and has many ways of evading the drugs used by oncologists to try and eliminate it.
Cancer
Mar 06, 2012 |
5 / 5 (4) |
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Some breast cancer spread may be triggered by a protein, study shows
Cancers rarely are deadly unless they evolve the ability to grow beyond the tissues in which they first arise. Normally, cells -- even early-stage tumor cells -- are tethered to scaffolding that helps to restrain ...
Cancer
Jan 17, 2012 |
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Promising target in treating and preventing the progression of heart failure identified
Researchers at Mount Sinai School of Medicine have identified a new drug target that may treat and/or prevent heart failure. The team evaluated failing human and pig hearts and discovered that SUMO1, a so-called "chaperone" ...
Cardiology
Sep 07, 2011 |
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