Oncology & Cancer

New understanding of how faulty metabolism triggers adrenal cancer

Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands. This discovery explains how impaired metabolism due to mutations in a key ...

Diseases, Conditions, Syndromes

COVID-19: New energy for flagging immune cells

In severe COVID-19 patients, metabolism produces insufficient amounts of certain energy-rich compounds called ketone bodies. However, these energy carriers are needed by two important cell types in the immune system in order ...

Immunology

Mitochondrial respiratory chain sustains inflammation

Northwestern Medicine investigators recently discovered that the mitochondrial respiratory chain—a series of protein complexes essential for a cellular respiration and energy production—is necessary for the activation ...

Diseases, Conditions, Syndromes

How herpesviruses awaken

Eight different herpesviruses are known to date in humans. They all settle permanently in the body after acute infection. Under certain circumstances, they wake up from this dormant phase, multiply and attack other cells. ...

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