Arthritis & Rheumatism

JAK signaling may be behind polymyalgia rheumatica

Janus tyrosine kinase (JAK) signaling may be involved in the pathogenesis of polymyalgia rheumatica (PMR), and tofacitinib may be an effective treatment, according to a pilot study published online June 29 in PLOS Medicine.

Oncology & Cancer

Researchers discover a new mechanism of cancer immune defense

An interdisciplinary team of researchers at the Otto-von-Guericke University in Magdeburg has gained new insights into how inflammatory mediators of pathogen defense can remotely drive cancer cells into death—an important ...

Immunology

Researchers uncover a cellular process that leads to inflammation

Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body's important inflammatory responses. Their findings, published in the journal Science Immunology, open ...

Cardiology

The lesser-known risk factors for heart disease

Most people know that the risk factors for heart disease are high blood pressure, smoking, raised cholesterol and being overweight. However, many people who have a heart attack do not have any of these traditional risk factors.

Immunology

New study gives clues on why exercise helps with inflammation

Researchers have long known that moderate exercise has a beneficial impact on the body's response to inflammation, but what's been less understood is why. New research coming out of York University done on a mouse model suggests ...

Immunology

Novel approach could redefine allergy treatment

For years, research and therapies for allergic asthma have been focused largely on targeting the inflammatory cytokines in the body that react to allergens and cause overproduction of mucus, wheezing and difficulty breathing. ...

Immunology

Immune cell movement worse in older females, mice study finds

According to a new study, older female mice had more immune cells entering areas of the body where they should not have, demonstrating that sex differences contribute to age-related inflammation, which should be considered ...

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