Surgery

How a common drug causes liver failure

Acetaminophen is a common pain reliever found in every pharmacy. However, it is also the No. 1 cause of acute liver failure in the United States. In the liver, acetaminophen is converted into a new compound that covalently ...

Diseases, Conditions, Syndromes

Fatality rates are high within two years of drug-induced liver injury

Most patients suffering liver toxicity due to medications or herbal or dietary supplements recover from the acute liver injury without long-term problems, but some do not survive the injury or they require liver transplantation. ...

Medications

FDA panel narrowly backs Cempra antibiotic

A panel of federal health advisers has narrowly recommended approval for an experimental antibiotic from Cempra Inc., a small North Carolina drugmaker.

Medical research

Liver-simulating device surpasses animal-based alternatives

The HEMIBIO project has developed a Hepatic Microfluidic Bioreactor mimicking the structure of the human liver. The project team is confident that the new device will eventually help remove the need for testing chemicals ...

Medications

Zydelig approved for three types of blood cancer

(HealthDay)—Zydelig (idelalisib) has been approved by the U.S. Food and Drug Administration to treat relapsed forms of blood cancer, including chronic lymphocytic leukemia (CLL), follicular B-cell non-Hodgkin lymphoma (FL) ...

Medications

Experimental diabetes drug makes comeback

A panel of federal health advisers has backed the benefits of an experimental diabetes drug that uses a new method to reduce blood sugar, setting aside previous concerns about the pill's safety.

Medical research

Can toxicity of a DNA drug be predicted and minimized?

New classes of therapeutic antisense oligonucleotides can have toxic effects on the liver. A novel machine learning-based approach used to predict the hepatotoxic potential of an antisense drug based on its chemical sequence ...

Medications

Britain bans herbal drug khat

British Home Secretary Theresa May on Wednesday announced a ban on the herbal stimulant khat, going against the advice of her own experts who said such a move was disproportionate.

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