Medical research
When cancer cells can't make their own fat, they eat more of it, study finds
A switch in fat metabolism from production to import could be exploited for cancer treatment, researchers say.
Jun 8, 2020
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182
News tagged with metabolic pathways
Medical research
Protein controls fat metabolism
Many foods—whether it's the mozzarella on your favorite pizza, the olive oil in salad dressing or hollandaise sauce during asparagus season—contain lots of fat. The fatty acids in these foods are among the essential nutrients ...
Mar 17, 2020
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292
Medications
Popular painkiller ibuprofen affects liver enzymes in mice
The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis. The study in laboratory mice also shows marked differences ...
Mar 11, 2020
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644
Genetics
TP53 gene variant in people of African descent linked to iron overload, may improve malaria response
In a study by The Wistar Institute and collaborators, a rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer response to bacterial ...
Jan 24, 2020
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135
Neuroscience
Cancer-like metabolism makes brain grow
The size of the human brain increased profoundly during evolution. A certain gene that is only found in humans triggers brain stem cells to form a larger pool of stem cells. As a consequence, more neurons can arise, which ...
Jan 7, 2020
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691
Oncology & Cancer
Glutamine-blocking drug slows tumor growth and strengthens anti-tumor response
A compound developed by Johns Hopkins researchers that blocks glutamine metabolism can slow tumor growth, alter the tumor microenvironment and promote the production of durable and highly active anti-tumor T cells.
Nov 8, 2019
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1739
Immunology
Researchers find potential new target for treatment of inflammatory disease
Researchers led by the University of Birmingham have found a potential new target to treat inflammatory disease.
Nov 7, 2019
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49
Medical research
Deciphering pancreatic cancer's invade and evade tactics
Two known gene mutations induce pathways that enhance pancreatic cancer's ability to invade tissues and evade the immune system. Researchers report the molecular details of this process, providing insights into druggable ...
Aug 5, 2019
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46
Diabetes
New insight into the biology of insulin release
In a new study, Yale researchers challenge a long-held assumption about how insulin-producing cells in the pancreas sense and respond to glucose. Their findings could lead to changes in the way that scientists approach the ...
Jul 18, 2019
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75
Medical research
Scientists identify metabolic features specific to the autistic brain
Skoltech scientists looked into the differences in the concentrations of multiple metabolites in healthy humans and individuals suffering from Autism Spectrum Disorder (ASD), gaining a deeper insight into the molecular processes ...
Jul 16, 2019
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447
